Phylogenetic Study of Influenza A Virus Subtype H5N1 in Iran and neighboring countries during 2003 and 2006

Najafi, Ali; Tavakoli, HamidReza; Mehrabi Tavana, Ali; Qorbanalizadgan, Mahdi; Ranjbar, Reza

year 4, Issue 1 And 2 (9-2010) Iran J Med Microbiol 2010, 4(1 And 2): 100-103 | Back to browse issues page

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Najafi A, Tavakoli H, Mehrabi Tavana A, Qorbanalizadgan M, Ranjbar R. Phylogenetic Study of Influenza A Virus Subtype H5N1 in Iran and neighboring countries during 2003 and 2006. Iran J Med Microbiol 2010; 4 (1 and 2) :100-103
URL: http://ijmm.ir/article-1-66-en.html

Phylogenetic Study of Influenza A Virus Subtype H5N1 in Iran and neighboring countries during 2003 and 2006

Ali Najafi¹

, HamidReza Tavakoli

², Ali Mehrabi Tavana³

, Mahdi Qorbanalizadgan¹

, Reza Ranjbar¹

1- Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran , Iran
2- Department of Nutrition, Health Research Center, Baqiyatallah University of Medical Sciences,Tehran, Iran , h.tavakoli1344@yahoo.com
3- Health Research Center , Baqiyatallah University of Medical Sciences, Tehran , Iran

Abstract: (13534 Views)

Background and Objectives: Influenza viruses, especially the subtype H1N1, arecontinuously evolving viruses, which have caused significant morbidity and mortality in Eastern Asian countries as well as in the Middle East. The aim ofthis study was to analyze genetic variations in hemaglutinin (HA) gene of the H1N1 viruses circulating in the countries neighboring Iran during 2003 till 2006 Material and methods: In this study we used multiple sequence alignment software for analysis of sequences. Genetic analyses were performed on 64 hemagglutinin gene in influenza A(H5N1) viruses derived from GeneBank reported in Iran and neighboring countries between 2003 and 2006. Results: HA phylogenetic analysis of these viruses showed multiple clades circulated around the world with regional prevalence patterns. Our analysis seems to indicate that the H1N1 viruses have initially entered Iranian borders from its northern bordering countries, such as Russia and the other CIS countries. They have subsequently spread inward towards the interior of mainland Iran. Conclusion:This study suggested that influenza A (H5N1) viruses might have migrated from neighboring countries of Iran to this country.

Keywords: Phylogenetic, influenza A, H5N1, Iran

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Type of Study: Brief Original Article | Subject: Medical Virology
Received: 2013/11/10 | Accepted: 2013/11/10 | ePublished: 2013/11/10