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Alivery Armando1 
, Dini Saniyah2 , Fasha Rudilla2 , Tamma Luthfi2 , I Made Agus Dwipayana2 , Maftuhatur Putri2 , Hammam Rofiqi2 , Muhammad Fadhil Kamaruddin2 , Nathania Nathania2 , Achmad iqbal Uswanas2 , Muhammad zulfikar Salim2 , Sulistiawati Sulistiawati3
, Dini Saniyah2 , Fasha Rudilla2 , Tamma Luthfi2 , I Made Agus Dwipayana2 , Maftuhatur Putri2 , Hammam Rofiqi2 , Muhammad Fadhil Kamaruddin2 , Nathania Nathania2 , Achmad iqbal Uswanas2 , Muhammad zulfikar Salim2 , Sulistiawati Sulistiawati3
1- Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. , aliveryraihanadaarmando@gmail.com
2- Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
3- 1. Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. 2. Departement of Public Health science-Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2- Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
3- 1. Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. 2. Departement of Public Health science-Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Abstract: (11 Views)
Background and Objective: Tuberculosis (TB) is an infectious disease responsible for the highest mortality than any other infectious disease in the world. Globally, Meningitis Tuberculosis (TBM) accounted for 1-2% of severe tuberculosis cases in children in 2019, and an estimated ~20,000 cases were reported. In Europe, up to 118 children were diagnosed with TB meningitis, and 9.6% of the patients died. The BCG vaccine is highly effective in preventing cases of Mycobacterium tuberculosis infection in children. Authors want to evaluate the impact of the BCG vaccine on the incidence of TB meningitis in children. Methods: This research was done using a meta-analysis method, by literature search in some databases, such as PMC, ScienceDirect, and Google Scholar.
Results: 7 literatures were identified according to the inclusion criteria formed by the previously determined PICO. The percentage of BCG vaccine history was 67.41% of the total sample and no history of BCG vaccine, which was 32.59%. Meningitis TB was diagnosed in as much as 24.3% of the total sample. Meta-analysis of this study was done by a fixed effect model (I2 0.00%) over samples of 7 publications meeting inclusion and exclusion criteria and yielded an average Odd ratio of 0.47 (CI 95% 0.38 - 0.57). Conclusion: There is an protective association between BCG vaccination and meningitis TB incidence in children
Results: 7 literatures were identified according to the inclusion criteria formed by the previously determined PICO. The percentage of BCG vaccine history was 67.41% of the total sample and no history of BCG vaccine, which was 32.59%. Meningitis TB was diagnosed in as much as 24.3% of the total sample. Meta-analysis of this study was done by a fixed effect model (I2 0.00%) over samples of 7 publications meeting inclusion and exclusion criteria and yielded an average Odd ratio of 0.47 (CI 95% 0.38 - 0.57). Conclusion: There is an protective association between BCG vaccination and meningitis TB incidence in children
Type of Study: Meta-analysis Article |
Subject:
Microbial Immunology
Received: 2025/01/27 | Accepted: 2025/06/30
Received: 2025/01/27 | Accepted: 2025/06/30
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Iranian Journal of Medical Microbiology by Farname is licensed under CC BY-NC 4.0
