year 18, Issue 1 (January - February 2024)                   Iran J Med Microbiol 2024, 18(1): 1-7 | Back to browse issues page

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Ghorbani N, Alamdary A, Khanizadeh S, Birjandi M, Ajorloo M. Epidemiological Study of Hepatitis D Virus in HBsAg Positive Patients in Khorramabad City, West of Iran, 2019. Iran J Med Microbiol 2024; 18 (1) :1-7
1- Hepatitis Research Center, Department of Virology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3- Department of Biostatistics and Epidemiology, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
4- Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran ,
Abstract:   (343 Views)

Background and Aim: Co-infection of HBV and HDV leads to more severe hepatitis, with a higher risk of acute liver failure and hepatocellular carcinoma (HCC). This study aimed to assess the prevalence of HDV in HBsAg-positive patients in Khorramabad, which has not been previously evaluated.
Materials and Methods: A total of 200 patients who tested positive for HBsAg were included in this study. Venous blood samples were collected in EDTA-free tubes. An ELISA test was performed to detect antibodies against HDV, and positive samples were further confirmed using RT-PCR. Population data were analyzed using SPSS software, and a P value ≤0.05 was considered statistically significant for all tests.
Results: Out of the total participants, there were 119 (59.5%) men and 81 (40.5%) women. The age of the patients varied from 5 to 89 years, with an average age of 49.66 years. The HDV ELISA test was performed on HBsAg-positive individuals, yielding positive results for 37 (18.5%) patients. Additionally, 10 (5%) patients showed borderline infection. The HDV RT-PCR results indicated that 42 (21%) individuals tested positive. The prevalence of HDV showed a statistically significant difference between urban and rural areas with respect to molecular RT-PCR testing (P=0.032). Additionally, women, married individuals, and drug addicts were found to be at a higher risk of HDV infection.
Conclusion: There is a high prevalence of HDV infection among patients who test positive for HBsAg in Khorramabad. Therefore, assessing the prevalence of HDV in HBsAg-positive patients can aid in ensuring timely diagnosis and appropriate treatment for these individuals.

Full-Text [PDF 510 kb]   (102 Downloads)    
Type of Study: Original Research Article | Subject: Medical Virology
Received: 2023/10/28 | Accepted: 2024/01/17 | ePublished: 2024/03/18

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