year 17, Issue 6 (November - December 2023)                   Iran J Med Microbiol 2023, 17(6): 646-653 | Back to browse issues page

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Nakhaie M, Ahmadinejad Farsangi S, Rezaei Zadeh Rukerd M, Shafieipour S, Arefinia N, Zahedi M J, et al . Hepatitis B Virus (HBV) and Occult Hepatitis B Virus (OBI) in Hemodialysis Patients: An Epidemiological Observational Study in Kerman, Iran (2022-2023). Iran J Med Microbiol 2023; 17 (6) :646-653
1- Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
2- Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences Kerman, Iran
3- Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
4- Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran
5- Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
6- Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences Kerman, Iran
7- Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ,
Abstract:   (480 Views)

Background and Aim: Viral infections are associated with augmented morbidity and mortality risk in Hemodialysis (HD) patients.
Materials and Methods: In this investigation, we have scrutinized the presence of hepatitis B virus (HBV), and occult hepatitis B virus infection (OBI), in HD patients. In this cross-sectional study, the blood samples and data from 200 hemodialysis patients referred to a dialysis center in Kerman, from January 2022 to March 2023 were collected. Anti-HBV antibodies and HBs Ag were analyzed in the specimens using an enzyme-linked immunosorbent assay (ELISA). All samples were tested for OBI by using a real-time polymerase chain reaction (PCR) assay.
Results: Of the 200 patients considered, 4 (2%) for HBs Ag were positive. Real-time PCR demonstrated OBI in 2 (1%) patients. The majority presence of viral infection was in the age group 50≥ years, self-employment, low education level, and diabetic patients. Furthermore, our study revealed that a higher percentage of HD patients were associated with low educational levels, self-employment, urban residence, and comorbidities such as diabetes and hypertension.
Conclusion: In this study, HBV antigen prevalence was 2%, and OBI prevalence was 1%, indicating a low HBV incidence in HD patients. Our study underscores the importance of lifestyle improvement, increased awareness among lower-educated and lower-skilled individuals, and rigorous disinfection practices in managing risk factors for hemodialysis patients, including HBV and OBI.

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Type of Study: Original Research Article | Subject: Medical Virology
Received: 2023/07/22 | Accepted: 2023/10/29 | ePublished: 2024/01/29

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