year 3, Issue 4 (Winter 2010)
Iran J Med Microbiol 2010, 3(4): 24-30 |
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Hosseinzadeh M, Khosravi A, Kaikhavani S, Malekshahi S, Khorasani R. Helicobacter pylori Antibody titer in Migraine patients in Ilam . Iran J Med Microbiol 2010; 3 (4) :24-30
URL: http://ijmm.ir/article-1-165-en.html
URL: http://ijmm.ir/article-1-165-en.html
1- )Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Iran.
2- )Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Iran. ,afrakhosravi@yahoo.co.uk
3- Department of Psycology, Faculty of Medicine, Ilam University of Medical Sciences, Iran
4- Public Health Center, Ilam, Iran.
2- )Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Iran. ,
3- Department of Psycology, Faculty of Medicine, Ilam University of Medical Sciences, Iran
4- Public Health Center, Ilam, Iran.
Abstract: (15696 Views)
Background and Objectives: Migraine is the most common headache in different communities and
approximately 12-15% of individuals are suffering worldwide. Recent studies have revealed a relationship
between Helicobacter pylori infection and migraine. The aim of presend study was to evaluate the antibody
titer against H.pylori in patients with migraine and comparison to healthy subjects.
Material & Methods: This case – control randomized study was carried out in patients whose migraine has
already been diagnosed referred to University neurology clinic and private medical sectors in Ilam, Iran.
Seventy migraine patients as the case group and 70 healthy individuals as control group were participated in
this study. The demographic criteria of both groups were identical. Blood samples were taken from all
subjects and was used for evaluation of IgG antibody titer against H.pylori by using ELISA method. The
mean antibody titer were compared in both groups.
Results: Household women had the highest prevalence of migraine (40%), which showed a correlation with
menstruation in 21 women (45.7%). Fifty three patients with migraine (75.7%) had gastrointestinal
disorders, which in 48 patients (68.6%), this was in correlation with certain nutritional habits. Stress was
reported as the most important cause of migraine in 15 patients (21.4%) that in 91.4% of them, headache was
followed by anxiety. In 51 patients (72.9%), sleep disorder was seen. The mean OD value of antibody titre
against H.pylori was 60.08 in case group and 21.82 in control group, which the difference was significant
(P<0.05).
Conclusion: The significant difference for the mean OD value to H.pylori among case and control groups in
present study, shows the importance of investigation of H. pylori infection in patients with classic migraine,
which needs more complementary tests. It is suggested that treatment of H.pylori infection may affect the
disease and probably cure the headache partially.
Type of Study: Original Research Article |
Subject:
Molecular Microbiology
Received: 2013/11/22 | Accepted: 2013/11/22 | ePublished: 2013/11/22
Received: 2013/11/22 | Accepted: 2013/11/22 | ePublished: 2013/11/22
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