Iranian Journal of Medical Microbiology

✅ Understanding the association between climatological and ecological change as determinants of disease emergence and redistribution will eventually help optimize preventive methodologies. Here, we review the scientific evidence of how global warming and patterns affect different human bacterial infectious diseases. 

✅  Highlights:

• Lysate of yeast probiotic S. cerevisiae decrease the expression of exoA gene

• S. cerevisiae can be used as therapeutic agent for infections

• Yeast probiotics has inhibitory effect on P. aeruginosa

✅ The LAMP-RT PCR technique is emerging as an appropriate alternative to the Real-Time RT-PCR method. This technique has some basic advantages such as constant temperature amplification, thermal cycle elimination, faster results, and potentially greater detection capacity. Therefore, the RT-LAMP-PCR can be used as a quick and cheap technique that can be used in all areas.

✅ Our study showed the existence of some Omicron-related mutations before the emergence of this variant in Khuzestan Province, Iran. In addition, it strengthened the possibility of unconfirmed variants, such as Epsilon entering Iran. It also provided a reference for studies that need to be aware of the circulating variants in Iran.

✅ We concluded that the expression and function of hepatocyte enzymes were increased following treatment with RDV.

✅ Data from current study indicated a higher concentration of salivary cortisol associated with increasing count of Mutans streptococci in comparison to the control group.

✅ Psoriasis patients treated with Adalimumab are as prone to COVID-19 infection. However, patients with severe psoriasis are more likely to develop COVID-19; this matter is not related to the use of Adalimumab, and it is not necessary to discontinue or change Adalimumab.

✅ Here, prompt setting up of RT-LAMP assays were carried out initially on designed gene constructs containing different SARS-CoV-2 target genes and simultaneous validation by RT-PCR. This approach could be used as an efficient solution where the clinical specimens may not initially be available, with feasibility for new target gene of interest to be inserted into MCS position.

✅  Highlights:

• High-level aminoglycoside resistance and frequency of aminoglycoside resistance associated genes among Enterococcus spp. isolated from Caspian horse feces were studied.

• Among 100 Enterococcus spp. 72% of isolates were resistant to at least one tested aminoglycoside.

• Among 100 Enterococcus spp. 38% of isolates showed high-level gentamicin and/or streptomycin resistance phenotype

• aac(6′)-Ie-aph(2″)-Ia was the most common resistance associated gene among Enterococcus spp.

• Our findings demonstrate the presence of multi aminoglycoside resistance encoding genes in Enterococcus spp., isolated from equine normal microflora.

✅ PCR assay was a sensitive & specific diagnostic tool in detecting Bacillus cereus with its enterotoxins genes directly from food samples, even in the presence of low numbers of B. cereus bacteria that traditional isolation and identification methods cannot detect.

✅  This study highlights the high antibiotic resistance, limited biofilm formation ability, and prevalence of virulence-associated genes in S. haemolyticus isolates from pregnant women with urinary tract infections. These findings underscore the clinical significance of this bacterium and the need for infection control measures.

✅  This study provides valuable insights into the prevalence, molecular characterization, and phylogenetic relationships of E. histolytica and G. intestinalis in Iraqi patients with diarrhea and intestinal disorders.

✅ In patients with urolithiasis, DNAs of Ureaplasma spp. were detected 2 times more frequently (20%) compared with controls (10%). We suggest the necessity to include detection of Ureaplasma spp. in the group of patients with urolithiasis and sterile leukocyturia.

✅  Here, we report a two-year-old girl initially admitted to urgent pediatric care and was diagnosed with Kawasaki disease associated with COVID-19 infection to highlight the clinical features and signs.

✅ The covid-19 pandemic began in China in November 2019 and spread globally by March 2020. In India Vaccine research, trials, and production were ramped up gradually. The Covishield vaccine trial was completed by December 2020 and the mass vaccination program started in January 2021. The mortality was far more in western and European countries (despite better health infrastructure) than in Asia or Africa.