The Relationship between Helicobacter Pylori and Extra-Gastrointestinal Infections

Darvishi, Mohammad; Noori, Majid; Nazer, Mohammad Reza; Soleiman-Meigooni, Saeed; Forootan, Mojgan

doi:10.30699/ijmm.14.6.543

year 14, Issue 6 (November - December 2020) Iran J Med Microbiol 2020, 14(6): 543-565 | Back to browse issues page

‎ 10.30699/ijmm.14.6.543

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Darvishi M, Noori M, Nazer M R, Soleiman-Meigooni S, Forootan M. The Relationship between Helicobacter Pylori and Extra-Gastrointestinal Infections. Iran J Med Microbiol 2020; 14 (6) :543-565
URL: http://ijmm.ir/article-1-1058-en.html

The Relationship between Helicobacter Pylori and Extra-Gastrointestinal Infections

Mohammad Darvishi¹

, Majid Noori¹

, Mohammad Reza Nazer²

, Saeed Soleiman-Meigooni¹

, Mojgan Forootan

1- Infectious Diseases and Tropical Medicine Research Center (IDTMRC), Department of Infectious Disease, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
2- Department of Infectious Diseases, Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Department of Gastroenterology, Gastrointestinal and liver Diseases Research Center (RCGLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran , drmojganforootan@gmail.com

Abstract: (5278 Views)

Helicobacter pylori (H. pylori) has been identified as the major agent in human gastric cancer by the International Agency for Research on Cancer (IARC). Infection caused by H. pylori plays a leading role in many disorders including duodenal and gastric ulcer, chronic gastritis, lymphoid tissue lymphoma, and gastric adenocarcinoma. In addition, growing evidence suggests that H. pylori interferes with many biological processes, causing or affecting the incidence of several extra-gastrointestinal disorders. The bacteria are known to cause iron deficiency anemia (IDA), vitamin B12 deficiency, and immune thrombocytopenic purpura (ITP). Latest studies suggest that H. pylori may contribute in many disorders such as insulin resistance, acute coronary syndrome, neurological diseases among others, which previously was attributed to other factors and conditions. There are several mechanisms proposed for H. pylori inducing low-grade chronic inflammation and the incidence of molecular imitation mechanisms. This present study discusses the most critical diseases related with the role of H. pylori and related infection (especially extra-gastrointestinal diseases) in these diseases.

Keywords: Helicobacter pylori, Gastrointestinal diseases, Extragastric diseases, Pathogenic factors

Full-Text [PDF 1907 kb] (1769 Downloads) | | Full-Text (HTML) (2585 Views)

Type of Study: Review Article | Subject: Medical Bacteriology
Received: 2020/02/11 | Accepted: 2020/09/9 | ePublished: 2020/10/27

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