سال 14، شماره 6 - ( آذر و دی 1399 )                   جلد 14 شماره 6 صفحات 543-565 | برگشت به فهرست نسخه ها


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Darvishi M, Noori M, Nazer M R, Soleiman-Meigooni S, Forootan M. The Relationship between Helicobacter Pylori and Extra-Gastrointestinal Infections. Iran J Med Microbiol. 2020; 14 (6) :543-565
URL: http://ijmm.ir/article-1-1058-fa.html
درویشی محمد، نوری مجید، ناظر محمد رضا، سلیمان میگونی سعید، فروتن مژگان. ارتباط هلیکوباکتر پیلوری با عفونت های خارج از دستگاه گوارش. مجله میکروب شناسی پزشکی ایران. 1399; 14 (6) :543-565

URL: http://ijmm.ir/article-1-1058-fa.html


1- مرکز تحقیقات بیماری های عفونی و طب گرمسیری (IDTMRC)، گروه هوا فضا و پزشکی، دانشگاه علوم پزشکی ارتش، تهران، ایران
2- گروه بیماری‌های عفونی، مرکز تحقیقات هپاتیت، دانشگاه علوم پزشکی لرستان، خرم آباد، ایران
3- گروه گوارش، مرکز تحقیقات بیماری‌های دستگاه گوارش و کبد (RCGLD)، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران ، drmojganforootan@gmail.com
چکیده:   (221 مشاهده)
آژانس بین ­المللی تحقیقات سرطان، هلیکوباکتر پیلوری (H. pylori) را به عنوان اصلی­ ترین کارسینوجن سرطان معده انسان در نظر گرفته است. عفونت حاصل از H. pylori دلیل اصلی بیماری ورم معده مزمن، زخم معده، زخم دوازدهه، آدنوکارسینومای معده و لنفوم بافت لنفوئیدی است. علاوه بر این شواهد رو به رشد نشان می­دهد که H. pylori با دخالت در بسیاری از فرایندهای بیولوژیکی، بروز بسیاری از بیماری­های خارج گوارشی را تعیین و یا تحت تاثیر قرار می­دهد. نقش H. pylori در کمبود ویتامین B12، آنمی فقر آهن (IDA)، پورپورای ترومبوسیتوپنیک ایمنی (ITP) قبلا شناخته شده است. شواهد تازه نشان می­دهد که H. pylori ممکن است در افزایش ابتلا به بیماری­های سندرم حاد کرنوری، مقاومت به انسولین، بیماری ­های عصبی و دیگر اختلالات که قبلا با شرایط دیگر در ارتباط بود، موثر باشد. مکانیسمهای متعددی برای عمل H. pylori از جمله القای التهاب مزمن با درجه پایین و وقوع مکانیسم­ های تقلید مولکولی در نظر گرفته شده است.در این مقاله مروری در مورد مهم ترین بیماری­ های مرتبط با عفونت H. pylori (بخصوص بیماری ­های خارج گوارشی) و نقش H. pylori در این بیماری­ ها بحث شده است. 
 
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نوع مطالعه: مروری | موضوع مقاله: باکتری شناسی پزشکی
دریافت: 1398/11/22 | پذیرش: 1399/6/19 | انتشار الکترونیک: 1399/8/6

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