Evaluation of antibacterial effects of silver nanoparticles with thiazole, imidazole and tetrahydropyridine derivatives against hospital gram negative bacterial pathogens

Ghasemi, Behzad; Najimi, Mohsen; Beyzaie, Hamid; Mirzai, Mojtaba; Majidiani, Hamidreza; Nasiri, Mehdi

year 10, Issue 4 (September - October 2016) Iran J Med Microbiol 2016, 10(4): 34-42 | Back to browse issues page

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Ghasemi B, Najimi M, Beyzaie H, Mirzai M, Majidiani H, Nasiri M. Evaluation of antibacterial effects of silver nanoparticles with thiazole, imidazole and tetrahydropyridine derivatives against hospital gram negative bacterial pathogens. Iran J Med Microbiol 2016; 10 (4) :34-42
URL: http://ijmm.ir/article-1-440-en.html

Evaluation of antibacterial effects of silver nanoparticles with thiazole, imidazole and tetrahydropyridine derivatives against hospital gram negative bacterial pathogens

Behzad Ghasemi

¹, Mohsen Najimi²

, Hamid Beyzaie³

, Mojtaba Mirzai⁴

, Hamidreza Majidiani⁵

, Mehdi Nasiri⁴

1- Young Researchers and Elite Club, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran , behzad.ghasemi99@gmail.com
2- Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
3- Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
4- Young Researchers and Elite Club, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
5- Department of Medical Parasitology and Entomology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Abstract: (11536 Views)

Background and Aim: Silver nanoparticles, thiazole, imidazole and tetrahydropyridine derivatives are all new antibacterial compounds that detection and comparison of their antibacterial effects can help to the selection of alternative antibiotics’ combinations against resistant bacterial strains especially gram- negative pathogenic bacteria in hospitals. In this regard, the aim of this study was comparison of antibacterial effects of silver nanoparticles, thiazole, imidazole and tetrahydropyridine derivatives on three gram -negative bacteria including Proteus mirabilis, Acinetobacter baumannii and Shigella dysenteriae.

Materials and Methods: To evaluate the antibacterial effects, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth microdilution was performed to determine the minimum inhibitory concentration (MIC).

Results: The results showed that thiazole, imidazole and tetrahydropyridine derivatives as well as silver nanoparticles had no inhibitory effect on A. baumannii. There was also no inhibitory effect from imidazole and tetrahydropyridine compounds besides 6a-c derivative of thiazole on bacteria. In this study, the inhibitory growth zone diameter of 17.3 and 18.5 was recorded for the inhibitory effect of the 6d derivative of thiazole on P. mirabilis and
S. dysenteriae mm and MIC of 125 and 62.5 µg/ml for them, respectively. Furthermore, the silver nanoparticle had inhibitory effect with inhibitory growth zone diameter of 13.4 and 15.2 mm and MIC of 1125 and 562.5 µg/ml on P. mirabilis and S. dysenteriae, respectively.

Conclusions: In this study the antibacterial potency of thiazole derivative was proved in comparison to the silver nanoparticle.

Keywords: Antibacterial effect, Silver nanoparticles, Thiazole, Iimidazoline, Tetrahydropyridine derivatives

Full-Text [PDF 908 kb] (3204 Downloads)

Type of Study: Original Research Article | Subject: Nosocomial infections
Received: 2015/06/20 | Accepted: 2015/10/1 | ePublished: 2016/10/16

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