year 4, Issue 3 (Fall 2010)                   Iran J Med Microbiol 2010, 4(3): 29-35 | Back to browse issues page

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Farahnifar A, Aghasadeghi M, Bahramali G, Sadat S M, Siadat S D, Moharez M, et al . HBV genotype and subtypes in HBV infected patients with and without HIV infection. Iran J Med Microbiol. 2010; 4 (3) :29-35
1- Department of Microbiology, Islamic Azad university, Karaj branche,Iran
2- ) Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran,Iran.
3- Iranian research centre for HIV/AIDS (IRCHA),Tehran university of medical sciences .Tehran,Iran
4- Medical technology research center, School of paramedical sciences, Shiraz university of medical sciences, Shiraz, Iran.
Abstract:   (12415 Views)
Background and Objective: The infections caused by hepatitis B virus (HBV) and HIV are a part of world health complications. Chronic hepatitis B affects nearly 10% of HIV-infected patients. Four million people are estimated to have HBV/HIV co-infection worldwide. The aim of the study was to determine the prevalence of HBV genotypes and subtypes in Iranian HBV infected patients with or without HIV coinfection.
Material and Methods: Sera from 58 Hepatitis B patients including 30(51.7%) with HBV infection and 28 (48.3%) with HIV/HBV co-infection were collected from medical centers in Tehran, Fars and Hormozgan provinces in years 2007-2009. DNA was extracted and surface gene (S region) was amplified by Nested PCR and subjected to sequencing. Phylogenic analysis was done using Mega4 software and drawing phylogenetic tree.
Results: Genotype D was the only genotype detected in both groups of patients. HBV subtypes observed in patients without HIV coinfection were ayw2 (27.90, 30%), ayw3(1.30, 3/3%) and ayw4 (2.6, 30.7%) while the subtypes found in HBV patients coinfected with HIV were included ayw2 (10.28, 7.35%), ayw3 (11.28, 39.3%) and ayw4 (7.28, 25%). The findings revealed a significant correlation between the types of infection (HBV/HIV co-infection or HBV mono infection) and the subtypes (P<0.001).
Conclusion: The individuals With HBV infection that carry ayw4 and ayw3 subtypes are more likely to be infected with HIV.
Keywords: HBV/HIV, HBV, Genotype, Subtype, Iran
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Type of Study: Original | Subject: Medical Bacteriology
Received: 2013/10/27 | Accepted: 2013/11/10 | ePublished: 2013/11/10

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