The Association Between Oral Candidiasis and ABO Blood Type in Infants in Kirkuk City, Iraq

Tajer Abdullah, Iman; M. Noori, Asoda; Lateef Mohammed , Bari; Beebany, Shakhawan

year 18, Issue 5 (September - October 2024) Iran J Med Microbiol 2024, 18(5): 301-307 | Back to browse issues page

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Tajer Abdullah I, M. Noori A, Lateef Mohammed B, Beebany S. The Association Between Oral Candidiasis and ABO Blood Type in Infants in Kirkuk City, Iraq. Iran J Med Microbiol 2024; 18 (5) :301-307
URL: http://ijmm.ir/article-1-2418-en.html

The Association Between Oral Candidiasis and ABO Blood Type in Infants in Kirkuk City, Iraq

Iman Tajer Abdullah¹

, Asoda M. Noori²

, Bari Lateef Mohammed¹

, Shakhawan Beebany³

1- Department of Biology, College of Science, University of Kirkuk, Kirkuk, Iraq
2- Department of Biology, College of Science, Garmian University, Sulaymaniyah, Iraq , asuda.nori@gmail.com
3- Department of Chemistry, College of Science, University of Kirkuk, Kirkuk, Iraq

Abstract: (453 Views)

Introduction and Objective: Candidiasis is the most prevalent mouth fungal infection. It is unclear whether variations in human blood types contribute to the onset of this illness. We aimed to identify the association between blood type antigens (ABO) and oral candidiasis in infants.
Material and methods: The specimens were taken from 110 infants with oral candidiasis symptoms, ages between 1 and 18 months, primarily from the Children's Hospital in Kirkuk City and a few outlying clinics. . Direct hemagglutination technique was conducted using monoclonal antibodies against human A, B, and Rh D antigens of the blood types. Macroscopic and microscopic evaluations were also performed. Chromogenic Agar Candida (CAC) was used to selectively develop the isolates with characteristic of Candida spp.
Results: The results showed significant difference between 72 positive infants (65%) and 38 infants without oral candidiasis (35%) (P<0.05). Most infected infants were males (67%), age groups 7-12 months (60%) with O+ (46%), A+ (26%) and Rh+ (92%) blood groups with significant differences (P<0.05). The Candida (C.) albicans scored the highest infection (85%) followed by the C. glabrata (8%), C. krusei (6%), and C. tropicalis (1%) with significant differences (P<0.05).
Conclusions: The prevalence of oral candidiasis in infants was related to the impaired immune status. Most infections with these diseases were in males age ranged 7-12 months with A+, O+, and Rh+ blood groups. C. albicans recorded the highest prevalence for the oral infants’ cases compared to the other studied candida types because of the highest pathogenicity.

Keywords: Oral candidiasis, C. albicans, Oral infection, Blood group (ABO)

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Type of Study: Original Research Article | Subject: Medical Mycology
Received: 2024/06/26 | Accepted: 2024/09/29 | ePublished: 2024/11/30

References

1. GonÇAlo RIC, de Souto Medeiros MR, Carlan LM, de Farias Morais HG, Gonzaga AKG, de Oliveira PT, et al. Oral Candidiasis in Head and Neck Cancer Patients: A Systematic Review. Oral Surg Oral Med Oral Radiol. 2024;137(6):e316. [DOI:10.1016/j.oooo.2023.12.772]

2. Sharma M, Chakrabarti A. Candidiasis and Other Emerging Yeasts. Curr Fungal Infect Rep. 2023;17(1):15-24. [DOI:10.1007/s12281-023-00455-3] [PMID] [PMCID]

3. Hellier SD, Wrynn AF. Beyond fluconazole: A review of vulvovaginal candidiasis diagnosis and treatment. Nurse Pract. 2023;48(9):33-9. [DOI:10.1097/01.NPR.0000000000000095] [PMID]

4. Gómez-Gaviria M, García-Carnero LC, Baruch-Martínez DA, Mora-Montes HM. The Emerging Pathogen Candida metapsilosis: Biological Aspects, Virulence Factors, Diagnosis, and Treatment. Infect Drug Resist. 2024;17:171-85. [DOI:10.2147/IDR.S448213] [PMID] [PMCID]

5. Hellstein JW, Marek CL. Candidiasis: Red and White Manifestations in the Oral Cavity. Head Neck Pathol. 2019;13(1):25-32. [DOI:10.1007/s12105-019-01004-6] [PMID] [PMCID]

6. Macias-Paz IU, Pérez-Hernández S, Tavera-Tapia A, Luna-Arias JP, Guerra-Cárdenas JE, Reyna-Beltrán E. Candida albicans the main opportunistic pathogenic fungus in humans. Rev Argent Microbiol. 2023;55(2):189-98. [DOI:10.1016/j.ram.2022.08.003] [PMID]

7. Ghojoghi A, Khodavaisy S, Mahmoudabadi AZ, Nazar E, Fatahinia M. Exploring the diversity of uncommon oral yeast species and associated risk factors among substance abusers in southwestern Iran. Sci Rep. 2024;14(1):1906. [DOI:10.1038/s41598-024-52105-4] [PMID] [PMCID]

8. Taverne-Ghadwal L, Kuhns M, Buhl T, Schulze MH, Mbaitolum WJ, Kersch L, et al. Epidemiology and Prevalence of Oral Candidiasis in HIV Patients From Chad in the Post-HAART Era. Front Microbiol. 2022;13:844069. [DOI:10.3389/fmicb.2022.844069] [PMID] [PMCID]

9. Lass-Flörl C, Kanj SS, Govender NP, Thompson GR, 3rd, Ostrosky-Zeichner L, Govrins MA. Invasive candidiasis. Nat Rev Dis Primers. 2024;10(1):20. [DOI:10.1038/s41572-024-00503-3] [PMID]

10. Azevedo MJ, Araujo R, Campos J, Campos C, Ferreira AF, Falcão-Pires I, et al. Vertical Transmission and Antifungal Susceptibility Profile of Yeast Isolates from the Oral Cavity, Gut, and Breastmilk of Mother-Child Pairs in Early Life. Int J Mol Sci. 2023;24(2):1449. [DOI:10.3390/ijms24021449] [PMID] [PMCID]

11. Khadija B, Abbasi A, Khan S, Nadeem M, Badshah L, Faryal R. Isolation of pathogenic Candida species from oral cavity of postpartum females, and its association with obstetric and dental problems. Microb Pathog. 2019;131:40-6. [DOI:10.1016/j.micpath.2019.03.022] [PMID]

12. Alkhars N, Al Jallad N, Wu TT, Xiao J. Multilocus sequence typing of Candida albicans oral isolates reveals high genetic relatedness of mother-child dyads in early life. PLoS One. 2024;19(1):e0290938. [DOI:10.1371/journal.pone.0290938] [PMID] [PMCID] []

13. Ota Y, Ito T, Sashida M, Hori E, Kimijima M, Narisawa N, et al. Association between Candida albicans and childhood dental caries in Japanese children. Pediatr Dent J. 2024;34(1):1-7. [DOI:10.1016/j.pdj.2023.12.001]

14. Ihsan Hussein M, Lateef Mohammed B, Khoursheed Abbas S. IL-6 and procalcitonin levels in hemodialysis patients with fungal infection. Res J Biotech. 2024;19(11):129-34. [DOI:10.25303/1911rjbt1290134]

15. Lateef Mohammed B, Tajer Abdullah I, Hussein Mohammed S, Beebany S. Phylogenetic Analysis of Scopulariopsis Brevicaulis Isolated From Diabetic Patients in Kirkuk City, Iraq. Iran J Med Microbiol. 2024;18(4):247-56. [DOI:10.30699/ijmm.18.4.247]

16. Al-Ani DKJ, Musa FH, Buniya HK. Isolation and identification of candida albicans from children patient with candidiasis from Ramadi city, Iraq. HIV Nurs. 2023;23(2):441-9.

17. Brawner DL, Cutler JE. Ultrastructural and biochemical studies of two dynamically expressed cell surface determinants on Candida albicans. Infect and Immun. 1986;51(1):327-36.‏ [DOI:10.1128/iai.51.1.327-336.1986] [PMID] [PMCID]

18. Qadir MI, Bashir H, Ahmad MH. Human Oropharyngeal Candidiasis: From Etiology to Current Treatment. Crit Rev Immunol. 2023;43(3):15-24. [DOI:10.1615/CritRevImmunol.2023049730] [PMID]

19. Kim JH, Ahn J-M. Clinical characteristics of patients with oral candidiasis. J Oral Med Pain. 2021;46(2):33-40. [DOI:10.14476/jomp.2021.46.2.33]

20. Qiu J, Roza MP, Colli KG, Dalben YR, Maifrede SB, Valiatti TB, et al. Candida-associated denture stomatitis: clinical, epidemiological, and microbiological features. Braz J Microbiol. 2023;54(2):841-8. [DOI:10.1007/s42770-023-00952-0] [PMID] [PMCID]

21. Keyvanfar A, Najafiarab H, Talebian N, Tafti MF, Adeli G, Ghasemi Z, et al. Drug-resistant oral candidiasis in patients with HIV infection: a systematic review and meta-analysis. BMC Infect Dis. 2024;24(1):546. [DOI:10.1186/s12879-024-09442-6] [PMID] [PMCID]

22. Cook A, Ferreras-Antolin L, Adhisivam B, Ballot D, Berkley JA, Bernaschi P, et al. Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study. Med Mycol. 2023;61(3):myad010. [DOI:10.1093/mmy/myad010] [PMID] [PMCID]

23. Tan CC, Lim D, Hisham NQ, Elias NA, Azli AS, Goh YC. Clinicopathological correlation of oral candidiasis-Our experience in a tertiary centre over two decades. Malays J Pathol. 2023;45(2):237-46.

24. Bao L, Du K, Gao J, Jiang R, Li B, Liu T. An analysis of the risk factors for invasive fungal infections in preterm infants and a discussion of prevention strategies. Technol Health Care. 2024;32(1):361-7. [DOI:10.3233/THC-230218] [PMID]

25. Rajendra Santosh AB, Muddana K, Bakki SR. Fungal Infections of Oral Cavity: Diagnosis, Management, and Association with COVID-19. SN Compr Clin Med. 2021;3(6):1373-84. [DOI:10.1007/s42399-021-00873-9] [PMID] [PMCID]

26. Neamah RA. Isolation and identification of some types of yeast Candida spp and study of their sensitivity to some antifungals. Iraqi J Human Soc Sci Res. 2024;4(12A-1).

27. Thanomsridetcha N, Tanakittiyakul P, Sub-In P, Pichaipaet P, Tangwattanachuleeporn M, Kitisin T, et al. The Potential Association of Human ABO Blood Group in Candida albicans Germination. Trends Sci. 2023;20(12):7116. [DOI:10.48048/tis.2024.7116]

28. Jain S, Shigli dk, Palekar U, Awinashe V, Jain A, Chiang K. Association between Oral Candidiasis and ABO blood types. J Appl Dent Med Sci. 2016;02:30-7.

29. Weiner A, Orange F, Lacas-Gervais S, Rechav K, Ghugtyal V, Bassilana M, et al. On-site secretory vesicle delivery drives filamentous growth in the fungal pathogen Candida albicans. Cell Microbiol. 2019;21(1):e12963. [DOI:10.1111/cmi.12963] [PMID]

30. Hajimaghsoodi S, Jafari Nodoushan AA, Akhavan Karbassi MH, Yazdanparast Y. The Relationship Between Salivary Candida Albicans Colony Count and Blood Group Antigens in Dentistry Students. Int J Med Lab. 2021;8(4):284-90. [DOI:10.18502/ijml.v8i4.8099]

31. Thakur SK, Sompal S, Dinesh Kumar N, Sinha AK. Link between human ABO blood groups with diseases influencing blood donors and recipients frequency at RBTC, Delhi, India. Bioinformation. 2023;19(5):576-81. [DOI:10.6026/97320630019576] [PMID] [PMCID]