year 18, Issue 1 (January - February 2024)                   Iran J Med Microbiol 2024, 18(1): 25-32 | Back to browse issues page


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Salavatiha Z, Ghorbani S, saadati H, Tavakoli A, Kiani S J, Ghasemi K et al . Investigation of Parvovirus B19 Infection Among Iranian Patients with Behcet’s Disease. Iran J Med Microbiol 2024; 18 (1) :25-32
URL: http://ijmm.ir/article-1-2172-en.html
1- Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Department of Bacteriology and Virology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Department of Medical Virology, York University, Toronto, Canada
5- Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , Monavari.hr@iums.ac.ir
Abstract:   (500 Views)

Background and Aim: Behcet's disease is rare and can cause inflammation in blood vessels throughout the body. Although various studies have been conducted on the possible association between BD and various pathogens such as viruses, the major cause of this disease is still unknown. Our study aimed to evaluate the presence of B19 in Behcet patients and healthy carriers.
Materials and Methods: For the current case-control study, we examined 103 samples including 54 males and 49 females, and 40 healthy control samples. At first, all samples were checked by ELISA technique and then, the level of B19 DNA was confirmed by Realtime PCR. Finally, the results of patients were compared to healthy control samples.
Results: A wide range of clinical manifestations was observed in the BD patient group. We found statistical differences in the prevalence of B19 IgG between patients and healthy populations (84.46% vs. 55%, respectively). However, the prevalence of B19 IgM was similar between patients and healthy control groups (4.58% vs. 2.5%, respectively). We couldn’t observe any detectable levels of B19 DNA in the patient and healthy carrier groups.
Conclusion: Our results failed to establish a relationship between B19 infection and BD development, but such a correlation has been reported. However, there may be an indirect association between genetically susceptible people after a viral infection.

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Type of Study: Original Research Article | Subject: Medical Virology
Received: 2023/11/16 | Accepted: 2024/02/4 | ePublished: 2024/03/18

References
1. Habibagahi MP, Habibagahi ZM, Saidmardani SMM, Sadeghian FM. No Definite Association between Human Parvovirus B19 Infection and Behçet Disease. Iran J Med Sci. 2015;40(6):493-500.
2. Wechsler FB, Davatchi F. Criteria for diagnosis of Behcet's disease. Lancet. 1990;335(8697):1078-80. [DOI:10.1016/0140-6736(90)92643-V]
3. Smith E, Yazici Y. Clinical manifestations and diagnosis of Behçet's syndrome. 2020. [DOI:10.1007/978-3-030-24131-5]
4. Kiafar M, Faezi ST, Kasaeian A, Baghdadi A, Kakaei S, Mousavi SA, et al. Diagnosis of Behçet's disease: clinical characteristics, diagnostic criteria, and differential diagnoses. BMC Rheumatol. 2021;5(1):2. [DOI:10.1186/s41927-020-00172-1] [PMID] [PMCID]
5. Karaarslan S, Ece C, Aygün H, Toklu SA. The Evaluation of Anesthesiological Approach Accompanying Spinal Anesthesia Applied in a Pregnant Woman with Behçet Disease: A Case Report. Haseki Tip Bulteni. 2017;55(4):325-7. [DOI:10.4274/haseki.50479]
6. Mikaniki E, Yusef Ghahari B, Mikaniki M. Frequency of ocular involvement in 100 cases of Behcet syndrome in Babol, North of Iran. Caspian J Intern Med. 2010;1(3):105-7.
7. Ogino R, Shimada K, Narai D, Goto M, Sato K, Katsuta Y, et al. Behçet's Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment. Tohoku J Exp Med. 2021;254(4):283-6. [DOI:10.1620/tjem.254.283] [PMID]
8. Güçlü E, Yavuz T, Tokmak A, Behçet M, Karali E, Öztürk Ö, et al. Nasal carriage of pathogenic bacteria in medical students: effects of clinic exposure on prevalence and antibiotic susceptibility. Eur Arch Oto Rhino L. 2007;264(1):85-8. [DOI:10.1007/s00405-006-0160-5] [PMID]
9. Sezer FN. The isolation of a virus as the cause of Behcet's diseases. Am J Ophthalmol. 1953;36(3):301-15. [DOI:10.1016/0002-9394(53)91372-5] [PMID]
10. Tong B, Liu X, Xiao J, Su G. Immunopathogenesis of Behcet's disease. Front Immunol. 2019;10:665. [DOI:10.3389/fimmu.2019.00665] [PMID] [PMCID]
11. Keseroglu HO, Gönül M. Infectious Agents in Etiopathogenesis of Behçet's. Behcet's disease: BoD-Books on Demand; 2017. p. 61. [DOI:10.5772/intechopen.68776]
12. Ghorbani S, Javanmard D, Kiani SJ, Tavakoli A, Moochani SS, Monavari SHR. No evidence of Human Cytomegalovirus infection among Behcet's Patients. Iran J Med Microbiol. 2020;14(2):133-7. [DOI:10.30699/ijmm.14.2.133]
13. Eglin RP, Lehner T, Subak-Sharpe JH. Detection of RNA complementary to herpes-simplex virus in mononuclear cells from patients with Behcet's syndrome and recurrent oral ulcers. The Lancet. 1982;320(8312):1356-61. [DOI:10.1016/S0140-6736(82)91268-5] [PMID]
14. Kim DY, Cho S, Choi MJ, Sohn S, Lee E-S, Bang D. Immunopathogenic Role of Herpes Simplex Virus in Behçet's Disease. Genet Res Int. 2013;2013:638273. [DOI:10.1155/2013/638273] [PMID] [PMCID]
15. Shahram F, Ghorbani S, Mahmoudi M, Akhlaghi M, Jadali Z, Imeni V, et al. Characterization of Occult Hepatitis B Virus Infection Among Iranian Patients with Behcet's Disease; Correlation with Clinical Status. Hepat Mon. 2021;21(1):e105078. [DOI:10.5812/hepatmon.105078]
16. Heegaard Erik D, Brown Kevin E. Human Parvovirus B19. Clin Microbiol Rev. 2002;15(3):485-505. [DOI:10.1128/CMR.15.3.485-505.2002] [PMID] [PMCID]
17. Shabani Z, Esghaei M, Keyvani H, Shabani F, Sarmadi F, Mollaie H, et al. Relation between parvovirus B19 infection and fetal mortality and spontaneous abortion. Med J Islam Repub Iran. 2015;29:197.
18. Monavari SH, Noorbakhsh S, Mollaie H, Fazlalipour M, Abedi Kiasari B. Human Bocavirus in Iranian children with acute gastroenteritis. Med J Islam Repub Iran. 2013;27(3):127-31.
19. Sammut R, Feghoul L, Xhaard A, Dhedin N, Robin M, Michonneau D, et al. Clinical and immune features of human parvovirus B19 infection in allogeneic stem cell transplantation recipients: A retrospective monocentric study. Transpl Infect Dis. 2023;25(5):e14118. [DOI:10.1111/tid.14118] [PMID]
20. Yaghoubi F, Dalil D, Tavakoli F, Hosseini SM. Relapsing anemia associated with parvovirus B19 infection in a kidney transplant recipient: A case report and review of the literature. Clin Case Rep. 2023;11(9):e7906. [DOI:10.1002/ccr3.7906] [PMID] [PMCID]
21. Sundaresan B, Shirafkan F, Ripperger K, Rattay K. The role of viral infections in the onset of autoimmune diseases. Viruses. 2023;15(3):782. [DOI:10.3390/v15030782] [PMID] [PMCID]
22. Zakrzewska K, Arvia R, Bua G, Margheri F, Gallinella G. Parvovirus B19: Insights and implication for pathogenesis, prevention and therapy. Aspects of Mol Med. 2023;1:100007. [DOI:10.1016/j.amolm.2023.100007]
23. Gallinella G. Chapter 8 - Molecular testing for parvoviruses. In: Coleman WB, Tsongalis GJ, editors. Diagnostic Molecular Pathology (Second Edition): Academic Press; 2024. p. 95-108. [DOI:10.1016/B978-0-12-822824-1.00043-2]
24. Javanmard D, Ziaee M, Ghaffari H, Namaei MH, Tavakoli A, Mollaei H, et al. Human parvovirus B19 and parvovirus 4 among Iranian patients with hemophilia. Blood Res. 2017;52(4):311-5. [DOI:10.5045/br.2017.52.4.311] [PMID] [PMCID]
25. Arabzadeh SAM, Alizadeh F, Tavakoli A, Mollaei H, Bokharaei-Salim F, Karimi G, et al. Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran. Blood Res. 2017;52(1):50-4. [DOI:10.5045/br.2017.52.1.50] [PMID] [PMCID]
26. Tavakoli A, Monavari SH, Mollaei H, Bokharaei-Salim F, Esghaei M, Keyvani H, et al. Frequency of human Parvovirus B19 among patients with respiratory infection in Iran. Med J Islam Repub Iran. 2018;32:38. [DOI:10.14196/mjiri.32.38] [PMID] [PMCID]
27. Rabah K, Rabah N, Deeb H, Kudsi M. Headache among Syrian patients Behcet's disease: A Case-Control Study. Research Square; 2023. [DOI:10.21203/rs.3.rs-2934194/v1]
28. Tóvári E, Mezey I, Hedman K, Czirják L. Self limiting lupus-like symptoms in patients with parvovirus B19 infection. Ann Rheum Dis. 2002;61(7):662-3. [DOI:10.1136/ard.61.7.662] [PMID] [PMCID]
29. Durigon EL, Erdman DD, Gary GW, Pallansch MA, Torok TJ, Anderson LJ. Multiple primer pairs for polymerase chain reaction (PCR) amplification of human parvovirus B19 DNA. J Virol Methods. 1993;44(2-3):155-65. [DOI:10.1016/0166-0934(93)90051-R] [PMCID]
30. Karbalaie Niya MH, Safarnezhad Tameshkel F, Panahi M, Bokharaei Salim F, Monavari SHR, Keyvani H. Human Papillomavirus Investigation in Head and Neck Squamous Cell Carcinoma: Initial Report from the Low Risk HPV Types Associations. Asian Pac J Cancer Prev. 2017;18(9):2573-9.
31. Nasseri S, Monavari SH, Keyvani H, Nikkhoo B, Vahabpour Roudsari R, Khazeni M. The prevalence of Human Papilloma Virus (HPV) infection in the oligospermic and azoospermic men. Med J Islam Repub Iran. 2015;29:272.
32. Javanmard D, Najafi M, Babaei MR, Karbalaie Niya MH, Esghaei M, Panahi M, et al. Investigation of CTNNB1 gene mutations and expression in hepatocellular carcinoma and cirrhosis in association with hepatitis B virus infection. Infect Agents Cancer. 2020;15(1):37. [DOI:10.1186/s13027-020-00297-5] [PMID] [PMCID]
33. Sadeghi F, Salehi-Vaziri M, Alizadeh A, Ghodsi SM, Bokharaei-Salim F, Fateh A, et al. Detection of Merkel cell polyomavirus large T-antigen sequences in human central nervous system tumors. J Med Virol. 2015;87(7):1241-7. [DOI:10.1002/jmv.24178] [PMID]
34. Galeone M, Colucci R, D'Erme AM, Moretti S, Lotti T. Potential Infectious Etiology of Behçet's Disease. Patholog Res Int. 2012;2012:595380. [DOI:10.1155/2012/595380] [PMID] [PMCID]
35. Nieto IG, Alabau JL. Immunopathogenesis of behçet disease. Curr Rheumatol Rev. 2020;16(1):12-20. [DOI:10.2174/1573397115666190415142426] [PMID]
36. Kerr JR. The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease. J Clin Pathol. 2016;69(4):279-91. [DOI:10.1136/jclinpath-2015-203455] [PMID]
37. Wong S, Brown KE. Development of an improved method of detection of infectious parvovirus B19. J Clin Virol. 2006;35(4):407-13. [DOI:10.1016/j.jcv.2005.12.008] [PMID]
38. Schwarz TF, Jäger G, Gilch S. Comparison of seven commercial tests for the detection of parvovirus B19-specific IgM. Zentralblatt für Bacteriology. 1997;285(4):525-30. [DOI:10.1016/S0934-8840(97)80114-4] [PMID]
39. Kozireva SV, Zestkova JV, Mikazane HJ, Kadisa AL, Kakurina NA, Lejnieks AA, et al. Incidence and clinical significance of parvovirus B19 infection in patients with rheumatoid arthritis.J. Rheumatol. 2008;35(7):1265-70. [PubMed]
40. Corcoran A, Doyle S. Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19. J Med Microbiol. 2004;53(6):459-75. [DOI:10.1099/jmm.0.05485-0] [PMID]
41. Lindblom A, Isa A, Norbeck O, Wolf S, Johansson B, Broliden K, et al. Slow Clearance of Human Parvovirus B19 Viremia following Acute Infection. Clin Infect Dis. 2005;41(8):1201-3. [DOI] [PubMed]
42. Irschick EU, Philipp S, Shahram F, Schirmer M, Sedigh M, Ziaee N, et al. Investigation of bacterial and viral agents and immune status in Behcet's disease patients from Iran. Int J Rheum Dis. 2011;14(3):298-310. [DOI:10.1111/j.1756-185X.2011.01601.x] [PMID]
43. Choi B, Lee ES, Sohn S. Vitamin D3 ameliorates herpes simplex virus-induced Behçet's disease-like inflammation in a mouse model through down-regulation of Toll-like receptors. Clin Exp Rheumatol. 2011;29(4 Suppl 67):S13-9.
44. Münke H, Stöckmann F, Ramadori G. Possible Association between Behçet's Syndrome and Chronic Hepatitis C Virus Infection. New Eng J Med. 1995;332(6):400-1. [DOI:10.1056/NEJM199502093320616] [PMID]
45. Kuethe F, Lindner J, Matschke K, Wenzel JJ, Norja P, Ploetze K, et al. Prevalence of parvovirus B19 and human bocavirus DNA in the heart of patients with no evidence of dilated cardiomyopathy or myocarditis. Clin Infect Dis. 2009;49(11):1660-6. [DOI:10.1086/648074] [PMID]
46. Habibagahi M, Habibagahi Z, Saidmardani S-M, Sadeghian F. No Definite Association between Human Parvovirus B19 Infection and Behçet Disease. Iran J Med Sci. 2015;40(6):493-500 [PMID] [PMCID]

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