The Effect of SARS-COV-2 Infection on the Hematological Markers

Fatahi, Seyed Majid; Khanizadeh, Sayyad; Safarzadeh, Ali; Alamdary, Ashkan; Razavi Nikoo, Hadi; Mohammadi, Rasool; Ghalandarian, Annahita; Ajorloo, Mehdi

doi:10.30699/ijmm.17.2.202

year 17, Issue 2 (March - April 2023) Iran J Med Microbiol 2023, 17(2): 202-210 | Back to browse issues page

‎ 10.30699/ijmm.17.2.202

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Fatahi S M, Khanizadeh S, Safarzadeh A, Alamdary A, Razavi Nikoo H, Mohammadi R, et al . The Effect of SARS-COV-2 Infection on the Hematological Markers. Iran J Med Microbiol 2023; 17 (2) :202-210
URL: http://ijmm.ir/article-1-1803-en.html

The Effect of SARS-COV-2 Infection on the Hematological Markers

Seyed Majid Fatahi¹

, Sayyad Khanizadeh²

, Ali Safarzadeh³

, Ashkan Alamdary⁴

, Hadi Razavi Nikoo⁵

, Rasool Mohammadi⁶

, Annahita Ghalandarian¹

, Mehdi Ajorloo

⁷

1- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
2- Department of Virology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Department of Biology, University of Padova, Padova, Italy
4- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
5- Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran
6- Department of Biostatistics and Epidemiology, School of Public Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
7- Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran , kmehdiajorloo@gmail.com

Abstract: (1806 Views)

Background and Aim: The novel coronavirus 2019 can lead to a vast range of respiratory complications, from mild to severe, driving to acute respiratory distress syndrome (ARDS). Common symptoms of COVID-19 include fever, fatigue, and dry cough, which can lead to complications, such as gastrointestinal disorders, and liver, cardiac, and renal dysfunctions. Alteration in the hematological markers is one of the COVID-19 diseases evaluated by our study.
Materials and Methods: In this study, hematological markers, including the levels of ESR, BS, Hb, HCT, MCV, MCH, MCHC, platelet, WBC, RBC, neutrophil, and lymphocyte, have been assessed and compared in both case and control groups. Furthermore, we assessed the associations between hematological parameters, clinical manifestations, and underlying medical conditions.
Results: Our data showed that RBC, HCT, and ESR were significantly associated with the novel coronavirus 2019 infection according to the disease progression. ESR (P= 0.022), Hb (P= 0.032), and BS (P= 0.01) levels in male people infected by SARS-CoV-2 proved to have a significant relationship with the control group. Moreover, BS, Hb, HCT, ESR, and neutrophil showed significant variations in diabetic individuals suffering from SARS-CoV-2 infection.
Conclusion: The dropping of the hematological markers in COVID-19 is linked with a noticeably increased mortality rate, while high neutrophil and BS levels are related to aggravation of the disease. Monitoring the hematological markers can contribute significantly to selecting the proper treatment and hamper of disease worsening.

Keywords: COVID-19, SARS-CoV-2, Hematological, Marker

Full-Text [PDF 539 kb] (531 Downloads) | | Full-Text (HTML) (372 Views)

Type of Study: Original Research Article | Subject: Medical Virology
Received: 2022/08/28 | Accepted: 2022/12/26 | ePublished: 2023/03/30

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