year 17, Issue 1 (January - February 2023)                   Iran J Med Microbiol 2023, 17(1): 1-6 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ramazanzadeh R, Marzban A, Khalili Fard Ardali J, Saki R, Esmaeil Lashgarian H, Shakib P. Anti-Mycobacterium tuberculosis Effects of Folk Medicinal Plants in Iran: A Mini-Systematic Review. Iran J Med Microbiol 2023; 17 (1) :1-6
1- Department of Microbiology, Ardabil University of Medical Sciences, Ardabil, Iran
2- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4- Department of Microbiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
5- Department of Medical Biotechnology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
6- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran ,
Abstract:   (1662 Views)

The emergence of drug resistance in Mycobacterium tuberculosis is a major challenge in tuberculosis treatment and control. In addition, multidrug resistance (MDR) and, more broadly, extensive drug resistance (XDR) have hampered treatment with common antibiotics. Thus, an herbal medicine containing antimicrobial capability can be a good alternative to antituberculosis drugs. In this study, we reviewed the effect of folk herbs in Iran as anti-Mycobacterium tuberculosis drugs. In this systematic analysis, keywords including medicinal plants, M. Tuberculosis infection, Tuberculosis disease, MTB, essential oils, and extracts were searched in Science Direct, Scopus, PubMed, Ovid, Cochrane, Scientific Information Database (SID), Iran Medex, Iran Doc, Magiran, and Google scholar where articles published from 2000 to 2020 were considered. The results indicated that Iranian native herbs such as Peganum harmala, Humulus lupulus, Capparis spinosa, Thymus vulgaris, Pulicaria gnaphalodes, Perovskia abrotanoides, Peganum harmala, Punica granatum, Digitalis sp., Citrus lemon, Rosa canina, Berberis vulgaris, Aloe vera, Mentha spp., Hypericum perforatum, Humulus lupulus, Trachyspermum copticum, Pelargonium graveolens, Levisticum officinale, and Dracocephalum kotschyi were all effective antibacterial against mycobacterial infection within 0.5 ug to 200 mg. Thymus vulgaris was shown to be the most effective than other antibacterial agents such as Streptomycin, Cycloserin Isoniazid, and Ethambutol (0.5-40 μg/mL). Herbal remedies may be an effective therapeutic option for antibiotic-resistant tuberculosis. Potential adverse effects and antibacterial properties, along with possible synergistic interactions with other plants and drugs, require further studies to clarify.

Full-Text [PDF 560 kb]   (471 Downloads) |   |   Full-Text (HTML)  (391 Views)  
Type of Study: Review Article | Subject: Medical Bacteriology
Received: 2022/04/5 | Accepted: 2022/08/3 | ePublished: 2023/01/20

1. Ramazanzadeh R, Shakib P, Rouhi S. Prevalence of Mycobacterium tuberculosis T family in different continents (2000-2012): A systematic review and meta-analysis. Int J Mycobacteriol. 2015;4:120. [DOI:10.1016/j.ijmyco.2014.11.060] [DOI:10.1016/j.ijmyco.2014.11.025] [DOI:10.1016/10.1016/j.ijmyco.2014.11.023]
2. Basso LA, Zheng R, Musser JM, Jacobs Jr WR, Blanchard JS. Mechanisms of Isoniazid Resistance in Mycobacterium tuberculosis: Enzymatic Characterization of Enoyl Reductase Mutants Identified in Isoniazid-Resistant Clinical Isolates. J Infect Dis. 1998;178(3):769-75. [DOI:10.1086/515362] [PMID]
3. Ramazanzadeh R, Shakib P, Rouhi S, Mohammadi B, Mohajeri P, Borji S. Molecular epidemiology of Mycobacterium tuberculosis isolates in Iran using spoligotyping. New Microbes New Infect. 2020;38:100767. [DOI:10.1016/j.nmni.2020.100767] [PMID] [PMCID]
4. Rouhi S, Rooshani D, Shakib P, Ahangar Kani F, Ramazanzadeh R. A 10-year survey on prevalence and occurrence rate of multidrug resistant Mycobacterium tuberculosis in Latin American and Mediterranean Families: A Systematic review and meta-analysis. Iran J Basic Med Sci. 2018;5(1):51-61. [DOI:10.29252/jbrms.5.1.51]
5. Vicente D, Basterretxea M, Dela Caba I, Sancho R, López-Olaizola M, Cilla G. Low antimicrobial resistance rates of Mycobacterium tuberculosis complex between 2000 and 2015 in Gipuzkoa, northern Spain. Enferm Infecc Microbiol Clin. 2019;37(9):574-9. [DOI:10.1016/j.eimc.2019.01.016] [PMID]
6. Chiang CY, Centis R, Migliori GB. Drug-resistant tuberculosis: Past, present, future. Respirology. 2010;15(3):413-32. [DOI:10.1111/j.1440-1843.2010.01738.x] [PMID]
7. Martin K, Ernst E. Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials. J Antimicrob Chemother. 2003;51(2):241-6. [DOI:10.1093/jac/dkg087] [PMID]
8. Melo JOD, Saltoratto ALF, Rizo WF, Jesus HCRD, Arrigoni-Blank MDF, Alves PB, et al. Cytotoxic effects of essential oils from three Lippia gracilis Schauer genotypes on HeLa, B16, and MCF-7 cells and normal human fibroblasts. 2014;13(2):2691-7. [DOI:10.4238/2014.April.8.12] [PMID]
9. Vanajothi R, Sudha A, Manikandan R, Rameshthangam P, Srinivasan P. Luffa acutangula and Lippia nodiflora leaf extract induces growth inhibitory effect through induction of apoptosis on human lung cancer cell line. Biomed Prev Nutr. 2012;2(4):287-93. [DOI:10.1016/j.bionut.2012.03.002]
10. Davoodi H, Ghaemi E, Mazandarani M, Shakeri F. Anti-mycobacterial and anti-inflammatory activity of Peganum harmala. J Chem Pharm Res. 2015;7(4):1611-6.
11. Serkani JE, Isfahani BN, Safaei HG, Kermanshahi RK, Asghari G. Evaluation of the effect of Humulus lupulus alcoholic extract on rifampin-sensitive and resistant isolates of Mycobacterium tuberculosis. Res Pharm Sci. 2012;7(4):235-42.
12. Ehsanifar A, Kazemipoor N, Fouladi B. Anti-mycobacterial activity of capparis spinosa l. Extract against clinical isolates of Mycobacterium tuberculosis. Asian Asian J Pharm Clin Res. 2017;10(8):181-5. [DOI:10.22159/ajpcr.2017.v10i8.17629]
13. Pourazar Dizaji Sh, Soleimani N, Afrugh P, Saedi S. In vitro Antibacterial Activity of Thymus vulgaris Essential Oil against Mycobacterium tuberculosis. Infect Epidemiol Microbiol. 2018;4(2):47-51.
14. Hozoorbakhsh F, Esfahani BN, Moghim S, Asghari G. Evaluation of the effect of Pulicaria gnaphalodes and Perovskia abrotanoides essential oil extracts against Mycobacterium tuberculosis strains. Adv Biomed Res. 2016;5:79. [DOI:10.4103/2277-9175.180991] [PMID] [PMCID]
15. Jahanpour S, Ghazisaidi K, Davoodi H, Mazandarani M, Samet M, Jahanpour N, et al. Antimicrobial Effects of Folk Medicinal Plants From the North of Iran Against Mycobacterium tuberculosis. Arch Pediatr Infect Dis. 2015;3(1 TB):e18098. [DOI:10.5812/pedinfect.18098]
16. Arjomandzadegan M, Emami N, Habibi G, Farazi A, Kahbazi M, Sarmadian H, et al. Antimycobacterial activity assessment of three ethnobotanical plants against Mycobacterium Tuberculosis: An In Vitro Study. Int J Mycobacteriol. 2016;5(5):108-9. [DOI:10.1016/j.ijmyco.2016.10.025] [PMID]
17. Rafiee B, Sadeghi D, Ghani S, Mosavari N, Hosseini SA. Antibacterial Effect of Aqueous and Ethanolic Extracts of Humulus Lupulus on Mycobacterium tuberculosis. Qom Univ Med Sci J. 2017;11(8):22-8.
18. Kardan Yamchi J, Mahboubi M, Kazemian H, Hamzelou G, Feizabadi MM. The chemical composition and antimycobacterial activities of Trachyspermum copticum and Pelargonium graveolens essential oils. Recent Pat Antiinfect Drug Discov. 2020;15(1):68-74. [DOI:10.2174/1574891X14666191028113321] [DOI:10.2174/22124071MTAxfOTUvx] [PMID]
19. Esfahani HM, Farimani MM, Ebrahimi SN, Jung JH, Aliahmadi A, Abbas-Mohammadi M, et al. Antibacterial components of Levisticum officinale koch against multidrug-resistant Mycobacterium tuberculosis. Pharmaceutical Sciences. 2020;26(4):441-7. [DOI:10.34172/PS.2020.38]
20. Asghari G, Nasr Esfahani B, Paydar P. Evaluating the effect of Dracocephalum kotschyi methanol extract on Mycobacterium tuberculosis. Res j pharmacogn. 2015;2(3):31-6.

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Medical Microbiology

Designed & Developed by : Yektaweb | Publisher: Farname Inc