Leukocytes Parameters, CRP, and Ferritin in Iranian Patients with COVID-19 Infection; A Cross-sectional Study

Karpians, Gevik; Piranfar, Vahhab; Yahyavi, Isar; Sepanian, Teni; Sepanian, Tadeh; Alizadeh, Samaneh; Chandhal, Arefeh

doi:10.30699/ijmm.15.3.361

year 15, Issue 3 (May - Jun 2021) Iran J Med Microbiol 2021, 15(3): 361-368 | Back to browse issues page

‎ 10.30699/ijmm.15.3.361

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Karpians G, Piranfar V, Yahyavi I, Sepanian T, Sepanian T, Alizadeh S et al . Leukocytes Parameters, CRP, and Ferritin in Iranian Patients with COVID-19 Infection; A Cross-sectional Study. Iran J Med Microbiol 2021; 15 (3) :361-368
URL: http://ijmm.ir/article-1-1305-en.html

Leukocytes Parameters, CRP, and Ferritin in Iranian Patients with COVID-19 Infection; A Cross-sectional Study

Gevik Karpians¹

, Vahhab Piranfar

², Isar Yahyavi³

, Teni Sepanian¹

, Tadeh Sepanian¹

, Samaneh Alizadeh⁴

, Arefeh Chandhal⁵

1- Department of Biochemistry, Medical Laboratory, Tehran, Iran
2- Research and Development Department, Farname Inc, Thornhill, Canada , vahab.p@gmail.com
3- Department of Molecular, Medical laboratory, Tehran, Iran
4- Department of Hematology, Medical Laboratory, Tehran, Iran
5- Department of Phlebotomy, Medical laboratory, Tehran, Iran

Abstract: (11837 Views)

Background and Objective: Coronavirus disease known as COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is affecting over 200 countries all over the world. This study was aimed to identify simple and swiftly available laboratory biomarkers to help facilitate effectual triage to categorize suspected COVID-19 patients.
Materials and Methods: According to a standard protocol, we collected clinical, etiological, and laboratory data of 140 patients who underwent diagnostic tests at Medical Laboratory Group, Tehran, Iran, from October 1 to November 28, 2020, based on PCR testing for SARS-CoV-2 infection. Leukocyte parameters, C-reactive protein (CRP) and, ferritin levels were measured in patients with positive PCR COVID-19 test.
Results: 140 patients with COVID-19 infection were included in the study. The median age in women was 41.5 (23-60) years and 45.3 (22-68) years in men. Based on RT-PCR result, there were significant differences for neutrophil, lymphocyte, and monocyte counts. Overall, 72.8% of patients had monocyte count more than 11 ×10⁹ /L. The mean neutrophil lymphocyte ratio (NLR) for women was 2.8 (SD: 1.8) and 2.6 (SD: 1.7) for men. Only in 15 patients (10.7%) with respiratory symptoms, CRP level was more than 5 mg/L.
Conclusion: We found a significant increase in monocyte count. Lymphopenia was also observed. In patients with respiratory symptoms, CRP was significantly higher than the normal reference range.

Keywords: Acute respiratory distress syndrome, Coronavirus, Cytokine release syndrome, Lymphopenia, Real Time PCR, Severe acute respiratory syndrome

Full-Text [PDF 608 kb] (1288 Downloads) | | Full-Text (HTML) (1639 Views)

Type of Study: Original Research Article | Subject: Medical Virology
Received: 2021/03/18 | Accepted: 2021/05/22 | ePublished: 2021/06/28

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