year 14, Issue 1 (January - February 2020)                   Iran J Med Microbiol 2020, 14(1): 43-30 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadi Hedayati M, Khani D. Relationship of Social Risk Factors and Helicobacter pylori Infection with Pathological Characteristics of Gastric Carcinoma. Iran J Med Microbiol 2020; 14 (1) :43-30
1- Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran ,
2- Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Abstract:   (3773 Views)
Background: Cancer is the priority of the World Health Organization (WHO) and a serious challenge in death of human untimely. Assessment of social and physiological risk factors in gastric carcinoma patients can reveal the reasons of high prevalence gastric carcinoma in Sanandaj city.
Methods: In a descriptive cross-sectional study, the variables of sex, age, education, occupation and active Helicobacter pylori infection were evaluated in two groups of 50 patients with gastritis and 50 patients with gastric carcinoma referred to Sanandaj hospitals during 2018-2019. After recording the results of each patient in the questionnaire, data were analyzed using SPSS 25 and Chi-square test.
Results: The results of this study showed that increasing of age, increased the prevalence of gastric carcinoma (P=0.000). On the other hand, the prevalence of gastric cancer decreased with increasing of the level of education and job stability, whereas the prevalence of gastric cancer in the illiterate group was the highest rate (P=0.000). The prevalence of gastric carcinoma in men was 4 times higher than women (P=0.001). G2 tumor was the highest prevalence amongst other tumor grades. The prevalence of H. pylori infection was 48% in patients with gastric carcinoma and 46% in patients with gastritis.
Conclusion: Prevalence of Social and physiological risk factors among patients with gastric carcinoma refer to Sanandaj hospitals is similar to societies with high prevalence.
Full-Text [PDF 1138 kb]   (2209 Downloads) |   |   Full-Text (HTML)  (7760 Views)  
Type of Study: Original Research Article | Subject: Medical Bacteriology
Received: 2020/01/19 | Accepted: 2020/02/5 | ePublished: 2020/03/14

1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424. [DOI:10.3322/caac.21492] [PMID]
2. Gholamreza Roshandel , Elham Partovipour, Fereshteh Salavati, et al. Cancer incidence in Iran in 2014: Results of the Iranian National Population based Cancer Registry. Cancer Epidemiology. 2019; 61: 50-8. [DOI:10.1016/j.canep.2019.05.009] [PMID]
3. Amoori N, Mahdavi S, Enayatrad M. Epidemiology and trend of stomach cancer mortality in Iran. International Journal of Epidemiologic Research. 2016;3(3):268-75.
4. Kourosh Zarea SB, Saeed Ghanbari and Hanna Tuvesson. Incidence of Gastrointestinal Cancers in Iran: A Systematic Review. Jundishapur J Chronic Dis Care. 2017;6(1):e37224. [DOI:10.17795/jjcdc-37224]
5. Catherine de Martel DFaMP. Gastric Cancer Epidemiology and Risk Factors. Gastroenterology Clinics of North America. 2013;42(2):219-40. [DOI:10.1016/j.gtc.2013.01.003] [PMID]
6. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019;14(1):26-38. [DOI:10.5114/pg.2018.80001] [PMID] [PMCID]
7. Lee YY, Derakhshan MH. Environmental and lifestyle risk factors of gastric cancer. Archives of Iranian Medicine (AIM). 2013 Jun 1;16(6).
8. Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F. Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention. Cancer Epidemiology Biomarkers & Prevention. 2014;23(5):700. [DOI:10.1158/1055-9965.EPI-13-1057] [PMID] [PMCID]
9. Caleyachetty R, Tehranifar P, Genkinger JM, Echouffo-Tcheugui JB, Muennig P. Cumulative social risk exposure and risk of cancer mortality in adulthood. BMC Cancer. 2015;15:945-. [DOI:10.1186/s12885-015-1997-z] [PMID] [PMCID]
10. Dean LT, Gehlert S, Neuhouser ML, Oh A, Zanetti K, Goodman M, et al. Social factors matter in cancer risk and survivorship. Cancer Causes Control. 2018;29(7):611-8. [DOI:10.1007/s10552-018-1043-y] [PMID] [PMCID]
11. Sitarz R, Skierucha M, Mielko J, Offerhaus GJA, Maciejewski R, Polkowski WP. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res. 2018;10:239-48. [DOI:10.2147/CMAR.S149619] [PMID] [PMCID]
12. Liu JY, Peng CW, Yang XJ, Huang CQ, Li Y. The prognosis role of AJCC/UICC 8th edition staging system in gastric cancer, a retrospective analysis. Am J Transl Res. 2018 Jan 15;10(1):292-303.
13. van Elsland D, Neefjes J. Bacterial infections and cancer. EMBO Rep. 2018 Nov;19(11):e46632. [DOI:10.15252/embr.201846632] [PMID] [PMCID]
14. Hur H, Lee SR, Xuan Y, Kim YB, Lim YA, Cho YK, et al. The Effects of Helicobacter pylori on the prognosis of patients with curatively resected gastric cancers in a population with high infection rate. Journal of the Korean Surgical Society. 2012;83(4):203-11. [DOI:10.4174/jkss.2012.83.4.203] [PMID] [PMCID]
15. Cheng XJ, Lin JC, Tu SP. Etiology and Prevention of Gastric Cancer. Gastrointestinal Tumors. 2016;3(1):25-36. [DOI:10.1159/000443995] [PMID] [PMCID]
16. Chichaklu AH, Hedayati MA, Esmaili FS, Ghaderi E, Shiri MH. Prevalence of hopQ alleles and relationship between cagA and vacA s1 with hopQ i gene in Helicobacter pylori strains isolated from patients with peptic ulcer referred to Towhid Hospital in Sanandaj (2014). Biosciences Biotechnology Research Asia. 2016 Mar 31;13(1):91-4. [DOI:10.13005/bbra/2008]
17. Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017;153(2):420-9. [DOI:10.1053/j.gastro.2017.04.022] [PMID]
18. Nagel G, Linseisen J, Boshuizen HC, Pera G, Del Giudice G, Westert GP, et al. Socioeconomic position and the risk of gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). International Journal of Epidemiology. 2007;36(1):66-76. [DOI:10.1093/ije/dyl275] [PMID]
19. Nagini S. Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol. 2012;4(7):156-69. [DOI:10.4251/wjgo.v4.i7.156] [PMID] [PMCID]
20. Yusefi AR, Bagheri Lankarani K, Bastani P, Radinmanesh M, Kavosi Z. Risk Factors for Gastric Cancer: A Systematic Review. Asian Pac J Cancer Prev. 2018;19(3):591-603.
21. Zali H, Rezaei-Tavirani M, Azodi M. Gastric cancer: prevention, risk factors and treatment. Gastroenterol Hepatol Bed Bench. 2011;4(4):175-85.
22. Lutgendorf SK, DeGeest K, Dahmoush L, et al. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity 2011;25(2):250-255. [DOI:10.1016/j.bbi.2010.10.012] [PMID] [PMCID]
23. Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncology 2010;6(12):1863-1881. [DOI:10.2217/fon.10.142] [PMID] [PMCID]
24. Rezayee A, Kurdistan Management and Planning Organization, Deputy of Statistics and Information, Moalem, 2016. Available from
25. Ang TL, Fock KM. Clinical epidemiology of gastric cancer. Singapore Med J. 2014;55(12):621-8. [DOI:10.11622/smedj.2014174] [PMID] [PMCID]
26. Saragoni L, Morgagni P, Gardini A, Marfisi C, Vittimberga G, Garcea D, et al. Early gastric cancer: diagnosis, staging, and clinical impact. Evaluation of 530 patients. New elements for an updated definition and classification. Gastric Cancer. 2013;16(4):549-54. [DOI:10.1007/s10120-013-0233-2] [PMID]
27. Saravle SM, Hedayati MA, Mohammadi E, Sheikhesmaeili F, Nikkhou B. Sirt1 gene expression and gastric epithelial cells tumor stage in patients with Helicobacter pylori infection. Asian Pacific journal of cancer prevention: APJCP. 2018;19(4):913.
28. Zandi S, Hedayati MA, Mohammadi E, Sheikhesmaeili F. Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients. Microbial pathogenesis. 2018 Mar 1;116:120-3. [DOI:10.1016/j.micpath.2017.12.078] [PMID]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Medical Microbiology

Designed & Developed by : Yektaweb | Publisher: Farname Inc