year 10, Issue 3 (July - August 2016)                   Iran J Med Microbiol 2016, 10(3): 68-72 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zadfettah F, Bolourian M, Sadegh A. Postvaccination Hepatitis B Antibody titer on students of Ardebil ‎College of Dentistry ‎. Iran J Med Microbiol 2016; 10 (3) :68-72
1- Endodontics Department, Ardebil University of Medical Sciences, Ardebil, Iran ,
2- Endodontics Department, Ardebil University of Medical Sciences, Ardebil, Iran
Abstract:   (10702 Views)

Background and Aim: Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic disease. Thus, the present study focused on antibody titer among HBV-vaccinated dental students in order to evaluate the efficacy of Hepatitis B vaccine and the associated factors.

Materials and Methods: descriptive observational study method was used, which included questionnaires and serologic tests. The questionnaires contained questions on personal specifications, according which as many as 76 individuals were qualified as the subjects of the study. Blood samples were taken from the subjects in order to run test on Hepatitis B by using ELISA test. Statistical analysis was done on the obtained data by using Chi-square test and Fisher’s exact test.

Results and Conclusions:: According to the obtained results, 6.6% of the students had a negative titer, while another 6.6% were in borderline situation; whereas 86.8% produced a positive titer. Furthermore, the results revealed that there was an insignificance difference between Hepatitis B Antibody titer values and variables such as gender and needlestick injuries (P≥0/05); whereas, Hepatitis B Antibody titer was significantly different for pre-clinical and clinical students. Based on achieved results, revaccination (booster shot) must be considered for the individuals with a negative Hepatitis B Antibody titer who are considered as high-risk group in the society.

Full-Text [PDF 715 kb]   (3668 Downloads)    
Type of Study: Brief Original Article | Subject: Medical Virology
Received: 2016/01/26 | Accepted: 2016/04/12 | ePublished: 2016/10/16

1. Centers for Disease Control. Protection against viral hepatitis. Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR 1990; 39:1-26. [Article]
2. Keeffe EB, Dieterich DT, Han S-H, Jacobson IM, Martin P, Schiff ER, Tobias H, Wright TL. A treatment algorithm for the management of chronic hepatitis B virus in the United States: an update. Clin Gastroenterol Hepatol 2006; 4: 936–62. [PubMed]
3. Arif M, Al-Faleh FZ, Al-Frayh AR, Ramia S. Reduction in the prevalence of antibody to hepatitis A virus among young Saudi adults: implications for hepatitis A vaccine. Saudi J Gastroenterol 1995; 1: 93-6. [PubMed]
4. Lemon SM, Thomas DL. Vaccines to prevent viral hepatitis. N Engl J Med 1997; 336: 196-204. [PubMed]
5. Ayazi F, Darvish Damavandi F. M. Shafie. [Evaluation of immunogenicity of hepatitis B vaccine in health care workers in Tehran, Iran]: The Eighth Congress of Infectious and Tropical Diseases; 2001: 136 (Persian).
6. Zali MR, Mohammad K, Noorbala AA, Noorimayer B, Shahraz S. Rate of hepatitis B seropositivity following mass vaccination in the Islamic Republic of Iran. East Mediterr Health J. 2005; 11(1-2): 62-7. [PubMed]
7. Sharifi M. Ghoreshian S. [Study on the immune effects of hepatitis B vaccination in health care personals of medicine university of Shahid Sadoughi of Yazd]. Scientific journal of Sadoughi of Yazd 1997; 1: 18-23 (Persian).
8. Hassanjuni R.M, Soleymani M, Asgharzade A.S. [Prevalence of HBV-DNA in chronic hepatitis B transmitters]. Scientific journal of Baboul 2002; 11(25): 32-7 (Persian).
9. Techasathit wichai, ratanasuwan winai, sonjai areeaue, et al. vaccination against hepatitis B virus: are thai medical students sufficiently?. J Med Assoc Thai, 2005, 88(3): 329-34. [PubMed]
10. Gillcrist JA. Hepatitis viruses A, B, C, D, E and G: implications for dental personnel. J Am Dent Assoc 1999; 130: 509-20. [PubMed]
11. Olubuyide IO, Ola SO, Aliyu B. Hepatitis B and C in doctors and dentists in Nigeria. QJM. 1997; 90: 417-22. [PubMed]
12. Mahboobi N, Agha-Hosseini F, Safari S, Lavanchy D, Alavian SM. [Hepatitis B virus infection in dentistry: a forgotten topic]. J Viral Hepat 2010; 17: 307-16 (Persian).
13. Amini S, Andalibi S, Mahmoodi M. [Anti-HBs Response and its Protective Effect in Children and Adults Receiving Hepatitis B Recombinant Vaccine, in Tehran]. Iran J Med Sci. 2002; 27(3); 101-1057 (in Persian). [Article]
14. Shokrgozar. MA, Shokri F. Antibody response to recombinant hepatitis B surface Antigen in healthy Adults following primary and supplementary vaccination. Irn J Med Sci 2001, 26(1): 10- 15. [Article]
15. Barsah C, Conn MI, Dimarino AJ, Marzano J, Allen ML: Serologic hepatitis B Immunity in vaccinated health care workers. Arch Intern Med 1999; 159:1481-1483. [PubMed]
16. Shin BM, Jeong KW. Distribution of anti-HBs levels in Korean adults. Yonsei Med J 2000; 41(1): 40-8. [PubMed]
17. Jahanbakhsh, A; Hatami Hosein, S. Eini, P; Hashemian, A.H. [Immune response against hepatitis B vaccine in health ‎care workers in Kermanshah]. Journal of improvement in 2003, 7: 48 - ‎53 (Persian).
18. Mujeeb S.A, Khatri Y, Khanani R. Frequency of parenteral exposure and seroprevalence of HBV, HCV and HIV among operation room personnel. Journal of Hospital Infection 1998; 38 (2): 133-137. [PubMed]
19. Bonni R, Leslie G. Evaluation of interventions to prevent needle stick injuries in health care. American J of preventive medicine 2000; 18(4):90-98. [PubMed]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Iranian Journal of Medical Microbiology

Designed & Developed by : Yektaweb | Publisher: Farname Inc