year 10, Issue 4 (September - October 2016)                   Iran J Med Microbiol 2016, 10(4): 55-62 | Back to browse issues page

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Mghbooli M, Mobaien A R, Ghoreyshi A, Moazzami M. The evaluation of Seroprevalence of anti-VZV antibody among acute Ischemic stroke patients in Comparison with control group. Iran J Med Microbiol. 2016; 10 (4) :55-62
1- Department of Neurology, Zanjan University of Medical Sciences, Zanjan, Iran ,
2- Department of Infectious diseases, Zanjan University of Medical Sciences, Zanjan, Iran
3- Department of Neurology, Zanjan University of Medical Sciences, Zanjan, Iran
4- Vali-e-Asr University Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract:   (6936 Views)

Background and Aim: Varicella zoster virus (VZV) infection of cerebral arteries produces a vasculopathy, manifesting most often as ischemic stroke and less often as hemorrhagic stroke. The aim of this study was to compare the prevalence of seropositivity of anti-VZV IgG between acute stroke patients and control group.

Materials and Methods: In this population-based cross-sectional study, 87 patients with acute ischemic stroke were selected as case group during 2014-2015,. Eighty-seven individuals without a history of stroke or other neurological disorders also were considered as control group based on their age and sex. VZV IgG was measured by the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed with SPSS V19- 16. Two groups were adjusted for socio-demographics and stroke risk factors.

Results: The mean age of the stroke patients  and control group were 71.33 years (± 10.95) and 67.69 years (± 11), respectively. The rate of seroprevalence of anti-VZV IgG was 95.5% in the stroke patients versus 96.3% in the control group. This difference was not statistically significant (p-value=0.5).

Conclusions: the Current study does not provide any evidence of an association between the immune response to VZV as a marker of prior infection and acute ischemic stroke.

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Type of Study: Original | Subject: Medical Virology
Received: 2015/07/31 | Accepted: 2016/01/19 | ePublished: 2016/10/16

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