year 18, Issue 4 (July - August 2024)                   Iran J Med Microbiol 2024, 18(4): 223-229 | Back to browse issues page


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I. Khaleel R, Haseeb Hwaid A, Younis Fadhil H, M. Aufi I, R. Aakef I, A. Hussein A et al . Crimean-Congo Hemorrhagic Fever (CCHF) Outbreak in Iraq During 2021. Iran J Med Microbiol 2024; 18 (4) :223-229
URL: http://ijmm.ir/article-1-2441-en.html
1- Department of Public Health, Central Public Health Laboratory (CPHL), Ministry of Health, Baghdad, Iraq
2- Department of Biology, College of Education for Pure Sciences, University of Diyala, Diyala, Iraq , Asmaa.haseeb@ymail.com
3- Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq
Abstract:   (686 Views)

Background and Aim: Crimean-Congo hemorrhagic fever (CCHF) is a viral infection transmitted by ticks. It is classified as a biosafety level (4) global pathogen with fatality rate of approximately 50%. This epidemiological survey aimed to explore the CCHF infection rate in Iraq during 2021.
Materials and Methods: Saved samples from May to December 2021 (61 samples) collected from the suspected patients who attended health departments in eight Iraqi governorates (Dhi Qar, Baghdad, Nineveh, Babel, Erbil, Diyala, Anbar and Muthanna) were examined. Molecular detection of CCHF viral RNA was performed via real-time reverse transcriptase-PCR (rRT-PCR). The results were analyzed by GraphPad Prism and SPSS software.
Results: CCHF was detected in 18 (29.5%) suspected samples. The epidemiological investigation documented 8 (44.44%) fatalities among the individuals who tested positive. Most diagnosed cases and deaths were in the age group ≤40 years, and the highest percentage of positive cases of CCHF infection (14, 77.8%) was detected in Dhi Qar with highly significant statistical difference (P<0.01) compared to other provinces.
Conclusion: Although the number of cases studied is relatively small and may not represent the broader situation of CCHF in Iraq, it can be considered a health concern in the region. Therefore, there is an urgent need to conduct epidemiological surveys to reduce the disease incidence and detect the extent of the spread of ticks that transmit the virus.

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Type of Study: Original Research Article | Subject: Medical Virology
Received: 2024/07/2 | Accepted: 2024/09/12 | ePublished: 2024/09/29

References
1. Kuehnert PA, Stefan CP, Badger CV, Ricks KM. Crimean-Congo hemorrhagic fever virus (CCHFV): a silent but widespread threat. Curr Trop Med Rep. 2021;8:141-7. [DOI:10.1007/s40475-021-00235-4]
2. Hawman DW, Feldmann H. Recent advances in understanding Crimean-Congo hemorrhagic fever virus. F1000Res. 2018;7:F1000 Faculty Rev-1715. [DOI:10.12688/f1000research.16189.1]
3. Ergonul O, Battal I. Potential sexual transmission of Crimean-Congo hemorrhagic fever infection. Jpn J Infect Dis. 2014;67(2):137-8. [DOI:10.7883/yoken.67.137]
4. World Health Organization (WHO). Crimean-Congo haemorrhagic fever. Who.int, Jan. 31, 2013. [updated 2022 May 23; cited 2023 March 5]. Accessed on 01 October 2024. Available online from: [https://www.who.int/news-room/fact-sheets/detail/crimean-congo-haemorrhagic-fever]
5. Emmerich P, Jakupi X, von Possel R, Berisha L, Halili B, Günther S, et al. Viral metagenomics, genetic and evolutionary characteristics of Crimean-Congo hemorrhagic fever orthonairovirus in humans, Kosovo. Infect Genet Evol. 2018;65:6-11. [DOI:10.1016/j.meegid.2018.07.010]
6. Adams MJ, Lefkowitz EJ, King AM, Harrach B, Harrison RL, Knowles NJ, et al. Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017). Arch Virol. 2017;162(8):2505-38. [DOI:10.1007/s00705-017-3358-5]
7. King AM, Lefkowitz EJ, Mushegian AR, Adams MJ, Dutilh BE, Gorbalenya AE, et al. Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018). Arch Virol. 2018;163(9):2601-31. [DOI:10.1007/s00705-018-3847-1]
8. Gargili A, Estrada-Peña A, Spengler JR, Lukashev A, Nuttall PA, Bente DA. The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: A review of published field and laboratory studies. Antivir Res. 2017;144:93-119. [DOI:10.1016/j.antiviral.2017.05.010]
9. Ahmad K. Outbreak of Crimean-Congo haemorrhagic fever in Pakistan. The Lancet. 2000;356(9237):1254. [DOI:10.1016/S0140-6736(05)73867-8]
10. Al-Abri SS, Al Abaidani I, Fazlalipour M, Mostafavi E, Leblebicioglu H, Pshenichnaya N, et al. Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues, challenges, and future directions. Int J Infect Dis. 2017;58:82-9. [DOI:10.1016/j.ijid.2017.02.018]
11. Perveen N, Khan G. Crimean-Congo hemorrhagic fever in the Arab world: a systematic review. Front Vet Sci. 2022;9:938601. [DOI:10.3389/fvets.2022.938601]
12. Sisman A. Epidemiologic features and risk factors of Crimean-Congo hemorrhagic fever in Samsun province, Turkey. J Epidemiol. 2013;23(2):95-102. [DOI:10.2188/jea.JE20120097]
13. Gürbüz E, Ekici A, Ünlü AH, Yilmaz H. Evaluation of seroprevalence and clinical and laboratory findings of patients admitted tohealth institutions in Gümüşhane with suspicion of Crimean-Congo hemorrhagic fever. Turk J Med Sci. 2021;51(4):1825-32. [DOI:10.3906/sag-2001-82]
14. Öncü S. Crimean-Congo hemorrhagic fever: an overview. Virol Sin. 2013;28:193-201. [DOI:10.1007/s12250-013-3327-4]
15. World Health Organization (WHO). Crimean-Congo Hemorrhagic Fever in Iraq. Who.int. [updated 2022 June 1 cited 2023 March 5]. Accessed on 01 October 2024. Available online from: [https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON386]
16. Alhilfi RA, Khaleel HA, Raheem BM, Mahdi SG, Tabche C, Rawaf S. Large outbreak of Crimean-Congo haemorrhagic fever in Iraq, 2022. IJID Regions. 2023;6:76-9. [DOI:10.1016/j.ijregi.2023.01.007]
17. Butt MH, Ahmad A, Misbah S, Mallhi TH, Khan YH. Crimean‐Congo hemorrhagic fever and Eid‐Ul‐Adha: A potential threat during the COVID‐19 pandemic. J Med Virol. 2021;93(2):618. [DOI:10.1002/jmv.26388]
18. World Health Organization (WHO). WHO provides laboratory equipment and diagnostic kits to enhance testing for viral haemorrhagic fevers in Iraq. Who.int, Jan. 16, 2023. Accessed on 01 October 2024. Available online from: [https://www.emro.who.int/iraq/news/who-provides-laboratory-equipment-and-diagnostic-kits-to-enhance-]
19. Al Salihi KA, Younise H, Zuhair Mahmoud Z, Hussain T. The 2022 crimean-congo hemorrhagic fever outbreak in Iraq. Austral J Vet Sci. 2024;56(1):35-40. [DOI:10.4206/ajvs.561.02]
20. Al-Mosawi AJ. Crimean-Congo hemorrhagic fever in Iraq (2018-2022) and an educational review. Biomed Biotechnol Sci. 2022;1(1):1-4. [DOI:10.5281/zenodo.6874121] [DOI:10.58489/2833-0951.BBS.1.1.003]
21. Ali HM. Epidemiological Profile of Crimean-Congo Hemorrhagic Fever, Iraq, 2018; Epidemiology Conference. August 10-11, 2020. London, UK. J Health Med Res. 2020;S(2). Accessed on 01 October 2024. Available online from: [https://www.iomcworld.org/articles/epidemiological-profile-of-crimeancongo-hemorrhagic-fever-iraq-20]
22. Tartar AS, Balın ŞÖ, Akbulut A, Demirdağ K. Crimean Congo hemorrhagic fever in Eastern Turkey: epidemiological and clinical evaluation. Türkiye Parazitolojii Dergisi. 2019;43(1):26. [DOI:10.4274/tpd.galenos.2019.6142]
23. Chapman LE, Wilson ML, Hall DB, LeGuenno B, Dykstra EA, Ba K, et al. Risk factors for Crimean-Congo hemorrhagic fever in rural northern Senegal. J Infect Dis. 1991;164(4):686-92. [DOI:10.1093/infdis/164.4.686]
24. Chinikar S, Moghadam AH, Parizadeh SJ, Moradi M, Bayat N, Zeinali M, et al. Seroepidemiology of crimean congo hemorrhagic Fever in slaughterhouse workers in north eastern iran. Iran J Public Health. 2012;41(11):72.
25. Yadav PD, Thacker S, Patil DY, Jain R, Mourya DT. Crimean-Congo hemorrhagic fever in migrant worker returning from Oman to India, 2016. Emerg Infect Dis. 2017;23(6):1005. [DOI:10.3201/eid2306.161950]
26. Pshenichnaya NY, Sydenko IS, Klinovaya EP, Romanova EB, Zhuravlev AS. Possible sexual transmission of Crimean-Congo hemorrhagic fever. Int J Infect Dis. 2016;45:109-11. [DOI:10.1016/j.ijid.2016.02.1008]
27. Spengler JR, Bergeron É, Spiropoulou CF. Crimean-Congo hemorrhagic fever and expansion from endemic regions. Curr Opin Virol. 2019;34:70-8. [DOI:10.1016/j.coviro.2018.12.002]
28. Akuffo R, Brandful JA, Zayed A, Adjei A, Watany N, Fahmy NT, et al. Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. BMC Infect Dis. 2016;16:1-5. [DOI:10.1186/s12879-016-1660-6]
29. Banafshi O, Hanafi-Bojd AA, Karimi M, Faghihi F, Beik-Mohammadi M, Gholami S, et al. Tick ectoparasites of animals in borderline of Iran-Iraq and their role on disease transmission. J Arthropod-Borne Dis. 2018;12(3):252. [DOI:10.18502/jad.v12i3.77]
30. Perveen N, Muzaffar SB, Al-Deeb MA. Ticks and tick-borne diseases of livestock in the Middle East and North Africa: A review. Insects. 2021;12(1):83. [DOI:10.3390/insects12010083]

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