سال 17، شماره 5 - ( مهر - آبان 1402 )                   جلد 17 شماره 5 صفحات 519-505 | برگشت به فهرست نسخه ها


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Jomehpour N, Soleimanpour S, Sankian M. Diagnosis of Latent Tuberculosis Infection: Promising Antigens. Iran J Med Microbiol 2023; 17 (5) :505-519
URL: http://ijmm.ir/article-1-2037-fa.html
جمعه پور نجمه، سلیمان پور سامان، سنکیان مجتبی. تشخیص عفونت سل نهفته: آنتی ژن های امیدوارکننده. مجله میکروب شناسی پزشکی ایران. 1402; 17 (5) :505-519

URL: http://ijmm.ir/article-1-2037-fa.html


1- گروه میکروب شناسی و ویروس شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
2- گروه میکروب شناسی و ویروس شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران ، Soleimanpours@mums.ac.ir
3- مرکز تحقیقات ایمونولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران
چکیده:   (571 مشاهده)

شیوع عفونت سل نهفته بر حسب منطقه به طور چشمگیری متفاوت است. در حال حاضر یک چهارم جمعیت جهان به سل نهفته مبتلا هستند. جهت رسیدن به اهداف سازمان بهداشت جهانی جهت پایان سل در سراسر جهان تا سال ۲۰۳۰ تعداد افراد مبتلا به سل نهفته که به سمت سل فعال پیشرفت می کنند باید کاهش یابد. تست های رایج که جهت تشخیص سل نهفته کاربرد دارد بر اساس پاسخ ایمنی به آنتی ژن های اختصاصی مایکوباکتریوم توبرکلوزیس به دو نوع تست های پوستی و تست های مبتنی بر اندازه گیری اینترفرون گاما تقسیم بندی می شوند. با این وجود هر دو تست دارای حساسیت پایینی هستند و نمی توانند بین سل نهفته و سل فعال تمایز قائل شوند. بنابراین، تکنیک‌های مختلفی مانند تشخیص سیتوکین های جایگزین و استفاده از آنتی ژن‌های جدید برای افزایش دقت این آزمایش‌ها در حال مطالعه هستند. علاوه بر این، آنتی ژن های جدید را می توان برای نظارت بر پیشرفت سل فعال و پاسخ به درمان استفاده کرد. هدف از این مطالعه بررسی ابزارهای تشخیصی و شواهد موجود در مورد آنتی ژن های جدید مایکوباکتریوم توبرکلوزیس برای تشخیص سل نهفته و انتخاب آنتی ژن های امیدوارکننده برای تحقیقات آینده است.

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نوع مطالعه: مقاله مروری | موضوع مقاله: باکتری شناسی پزشکی
دریافت: 1402/3/16 | پذیرش: 1402/6/18 | انتشار الکترونیک: 1402/9/8

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