Monavari H, Hamkar R, Norooz-Babaei Z, Adibi L, Noroozi M, Ziaei A. Antiviral effect assay of twenty five species of various medicinal plants families in Iran. Iran J Med Microbiol 2007; 1 (2) :49-59
URL:
http://ijmm.ir/article-1-85-en.html
1- Department of Virology, School of Medicine, IranUniversity of Medical Sciences
2- Department of Virology, School of Public Health,Medical Sciences, University of Tehran, Tehran, Iran , rhamkar@sina.tums.ac.ir
3- Department of Virology, School of Public Health,Medical Sciences, University of Tehran, Tehran, Iran
4- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: (57114 Views)
Background and Objectives: Medicinal plants have been traditionally used for different kinds of ailments including infectious diseases. There is an increasing need for substances with antiviral activity since the treatment of viral infections with the available antiviral drugs often lead to the problem of viral resistance. There is a need to search for new and more effective antiviral agents, therefore in the present study 25 plants with ethno-medical background from different families were screened for antiviral activity against HSV-1, Adenovirus type 5, Echovirus type 11, Measles virus and Rotavirus.
Material and methods: Different parts of the plants collected from Iran were extracted with aqueous solvents to obtain crude extracts. These extracts were screened for their cytotoxicity against Vero, BSC-1, Hep-II and RD cell lines by micro-culture neutral red dye absorption and microscopically follow up forCPE. Antiviral properties of the plant extracts were determined by cytopathic effect inhibition assay and plaque reduction assay.
Results: Four plants extract Nymphea alba, Rhus coriaria L., Chelidonium majusand Terminalia chebula Retzexhibited significant antiviral activity against HSV-1 and adenovirus type 5 at non-toxic concentration. The extracts of Chelidonium majus showed great anti viral activity against HSV-1 andpartial activity against adenovirus at higher concentrations.
Conclusion: Some of the medicinal plants have shown antiviral activity. Further research is needed to elucidate the active constituents of these plants which may be useful in the development of new and effective antiviral agents.
Type of Study:
Original Research Article |
Subject:
Medical Virology Received: 2013/11/11 | Accepted: 2013/11/11 | ePublished: 2013/11/11