Evaluation of Herpes Simplex Virus IgG Specific Antibody and high-sensitivity C-Reactive Protein Levels in Patients with Coronary Artery Disease

Taleb Jannesar Hosseini, Mohammad; Ghane, Maryam

year 12, Issue 1 (March - April 2018) Iran J Med Microbiol 2018, 12(1): 61-67 | Back to browse issues page

Mendeley

Zotero

RefWorks

Taleb Jannesar Hosseini M, Ghane M. Evaluation of Herpes Simplex Virus IgG Specific Antibody and high-sensitivity C-Reactive Protein Levels in Patients with Coronary Artery Disease. Iran J Med Microbiol 2018; 12 (1) :61-67
URL: http://ijmm.ir/article-1-789-en.html

Evaluation of Herpes Simplex Virus IgG Specific Antibody and high-sensitivity C-Reactive Protein Levels in Patients with Coronary Artery Disease

Mohammad Taleb Jannesar Hosseini¹

, Maryam Ghane

1- Department of Biology, Faculty of Science, Islamic Azad University Islamshahr Branch, Islamshahr, Iran
2- Department of Biology, Faculty of Science, Islamic Azad University Islamshahr Branch, Islamshahr, Iran , maryamghaneh@yahoo.com

Abstract: (16227 Views)

Background and Aims: Coronary artery disease (CAD) is a major cause of mortality worldwide. Infectious agents such as herpes simplex virus (HSV) may be implicated in the pathogenesis of atherosclerosis. The aim of this study was to survey the prevalence of IgG antibodies against HSV in patients with coronary artery disease and to determine the mean of high-sensitivity C-reactive protein(hs-CRP) in these patients.
Materials and Methods: 40 patients being evaluated for atherosclerosis by coronary angiography along with 40 healthy individuals as a control group were examined in this research. Assessment of hs-CRP was carried out by nephelometry and virus-specific IgG antibodies by Enzyme-linked Immunosorbent Assay (ELISA).
Results and Conclusions: Results showed that the levels of hs-CRP were significantly higher among patients compared to that of control group (P<0.05). Higher percentage of patients had anti-HSV (78.4%) compared to healthy individuals (21.6%). Significant correlation was detected between HSV seropositivity and CAD. The mean of hs-CRP was significantly higher in subjects with HSV positive serology. In conclusion, the seropositivity of HSV along with high levels of hs-CRP may be a risk factor for coronary atherosclerosis.

Keywords: Atherosclerosis, Herpes Simplex Virus, C-Reactive Protein

Full-Text [PDF 805 kb] (4756 Downloads)

Type of Study: Brief Original Article | Subject: Medical Virology
Received: 2017/11/26 | Accepted: 2018/03/14 | ePublished: 2018/05/14

References

1. Kalampogias A, Siasos G, Oikonomou E, Tsalamandris S, Mourouzis K, Tsigkou V, et al. Basic Mechanisms in Atherosclerosis. The Role of Calcium. Med Chem. 2016;12(2):103-13. [DOI]

2. Hartman J, Frishman WH. Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy. Cardiol Rev. 2014;22(3):147-51. [DOI] [PubMed]

3. Rosenfeld ME, Campbell LA. Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis. Thromb Haemost. 2011;106(5):858-67. [PubMed]

4. Al-Ghamdi A. Role of herpes simplex virus-1, cytomegalovirus and Epstein-Barr virus in atherosclerosis. Pak J Pharm Sci. 2012;25(1):89-97. [PubMed]

5. Nikolopoulou A, Tousoulis D, Antoniades C, Petroheilou K, Vasiliadou C, Papageorgiou N, et al. Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1. Int J Cardiol. 2008;130(2):246-50. [DOI] [PubMed]

6. Reszka E, Jegier B , Wasowicz W, Lelonek M, Banach M, Jaszewski R. Detection of infectious agents by polymerase chain reaction in human aortic wall. Cardiovasc Pathol. 2008;17(5):297-302. [DOI] [PubMed]

7. Ibrahim AI, Obeid MT, Jouma MJ, Moasis GA, Al-Richane WL, Kindermann I, et al. Detection of herpes simplex virus, cytomegalovirus and Epstein-Barr virus DNA in atherosclerotic plaques and in unaffected bypass grafts. J Clin Virol. 2005;32(1):29-32. [DOI] [PubMed]

8. Marchi S, Trombetta CM, Gasparini R, Temperton N, Montomoli E. Epidemiology of herpes simplex virus type 1 and 2 in Italy: a seroprevalence study from 2000 to 2014. J Prev Med Hyg. 2017;58(1):27–33.

9. Malary M, Ghasem Abedi, Hamzehgardeshi Z, Afshari M, Moosazadeh M. The prevalence of herpes simplex virus type 1 and 2 infection in Iran: A meta-analysis. Int J Reprod Biomed (Yazd). 2016;14(10):615–24. [DOI]

10. Span A, Dam-Mieras M, Mullers W, Endert J, Muller A, Bruggeman C. The effect of virus infection on the adherence of leukocytes or platelets to endothelial cells. Eur J Clin Invest. 1991;21(3):331-8. [DOI]

11. Zhang X, Tang Q, Xu L. Herpes simplex virus 2 infects human endothelial ECV304 cells and induces cell apoptosis synergistically with ox-LDL. Journal Toxicol Sci. 2014;39(6):909-17. [DOI]

12. Kis Z, Sas K, Gyulai Z, Treso B, Petrovay F, Kapusinszky B, et al. Chronic infections and genetic factors in the development of ischemic stroke. New Microbiol. 2007;30(3):213-20. [PubMed]

13. Hagiwara N, Toyoda K, Inoue T, Shimada H, Ibayashi S, Iida M, et al. Lack of association between infectious burden and carotid atherosclerosis in Japanese patients. J Stroke Cerebrovasc Dis. 2007;16(4):145-52. [DOI] [PubMed]

14. Asoode A, Yavarian J, Ahmadkhaniha H, Eshraghian M, Marashi SM, Ghaemi K, et al. Epstein-Barr virus and herpes simplex infection assessment in schizophrenia and bipolar patients compared to healthy subjects. J Birjand Univ Med Sci. 2016;23(2):149-57.

15. Karami A, Palizi S, Ahangar H, Jalil Vand A, Mazloom Zadeh S, Mohebbi N, et al. Seroprevalence of Cytomegalovirus and Herpes Simplex Virus in Patients with Coronary Artery Diseases (CAD). J Zanjan Univ Med Sci. 2016;24(103):91-101.

16. Mundkur LA, Rao VS, Hebbagudi S, Shanker J, Shivanandan H, Nagaraj RK, et al. Pathogen burden, cytomegalovirus infection and inflammatory markers in the risk of premature coronary artery disease in individuals of Indian origin. Exp Clin Cardiol. 2012;17(2):63-8. [PubMed]

17. Wu Y, Sun D, Wang Y, Liu W, Yang J. Herpes simplex virus type 1 and type 2 infection increases atherosclerosis risk: Evidence based on a meta-analysis. Biomed Res Int. 2016;2016:2630865.

18. Epstain SE, Zhu J, Najafi AH, Burnett MS. Insights into the role of infection in atherogenesis and in plaque rupture. Circulation. 2009;119(24):3133-41. [DOI] [PubMed]

19. Piranfar MA. The correlation between high-sensitivity C-Reactive Protein (hsCRP) serum levels and severity of coronary atherosclerosis. Int Cardiovasc Res J. 2014;8(1):6–8.

20. Vahdat K, Jafari SM, Pazoki R, Nabipour I. Concurrent increased high sensitivity C-reactive protein and chronic infections are associated with coronary artery disease: a population-based study. Indian J Med Sci. 2007;61(3):135-43. [DOI]