[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: year 12, Issue 3 (July - August 2018) ::
Iran J Med Microbiol 2018, 12(3): 0-0 Back to browse issues page
Function and Medical Application of Bacterial Extracellular Vesicles
Maryam Ebrahimi Vargoorani 1, Mohammad Hossein Modarressi 2, Mojgan Sheikhpour 3, Seyed Davar Siadat 4
1- Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran
2- Department of Medical Genetics, Faculty of Medicine, University of Tehran, Tehran, Iran
3- Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
4- Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran , d.siadat@gmail.com
Abstract:   (468 Views)
Extracellular vesicles are nanoscale particles which were identified about fifty years ago. Since identifying these nanostructures, it has been found that almost all of the gram-negative bacteria secrete extracellular vesicles during their normal growth. Today, the production of membrane vesicles has been reported by gram-positive bacteria, parasites, fungi, and mycobacteria. Since these nanoscale particles carry many of the bacterial components such as DNA, RNA, protein, endotoxin, and virulence molecules, they play a very important role in interacting with the environment and other bacteria. For this reason, many of these vesicles are corresponded to the transmission of pathogens, antigenic protein compounds, and the development of non-cellular vaccines, as well as drug delivery agents. The studies, have been carried in this field so far, have been focused on the pathogenic and physiological roles of these nanostructures in cross-species relationships. The focus of this article is on the role of extracellular bacterial vesicles and pathological and physiological functions which contribute to the interactions between bacteria and bacterium-host. Since these nanostructures play significant role in pathogenesis, gene transduction, regulation of gene expression, immune response regulation, and cellular signaling, further studies are needed on the medical application of these nanostructures as a new generation of vaccines, adjuvants, drug delivery agents.
Keywords: Extracellular vesicles, adjuvants, vaccine, bacterium, medical application
     
Type of Study: Review | Subject: Medical Bacteriology
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ebrahimi Vargoorani M, Modarressi M H, Sheikhpour M, Siadat S D. Function and Medical Application of Bacterial Extracellular Vesicles. Iran J Med Microbiol. 2018; 12 (3)
URL: http://ijmm.ir/article-1-785-en.html


year 12, Issue 3 (July - August 2018) Back to browse issues page
مجله میکروب شناسی پزشکی ایران Iranian Journal of Medical Microbiology
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3764