The frequency of integrons of antibiotic resistant  in Stenotrophomonas maltophilia isolates in Hamadan/Iran

Hajiahmadi, Fahime; Safari, Nasim; Alijani, Pegah; Mordaddi, Alireza; Arabestani, Mohammad Reza

year 10, Issue 4 (September - October 2016) Iran J Med Microbiol 2016, 10(4): 10-16 | Back to browse issues page

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Hajiahmadi F, Safari N, Alijani P, Mordaddi A, Arabestani M R. The frequency of integrons of antibiotic resistant in Stenotrophomonas maltophilia isolates in Hamadan/Iran. Iran J Med Microbiol 2016; 10 (4) :10-16
URL: http://ijmm.ir/article-1-536-en.html

The frequency of integrons of antibiotic resistant in Stenotrophomonas maltophilia isolates in Hamadan/Iran

Fahime Hajiahmadi¹

, Nasim Safari¹

, Pegah Alijani¹

, Alireza Mordaddi¹

, Mohammad Reza Arabestani

1- Department of Microbiology,Hamadan University of Medical Sciences, Hamadan, Iran
2- Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran , mr_arabestani@yahoo.com

Abstract: (8842 Views)

Background and Aim: Stenotrophomonasmaltophilia is an important multidrug-resistant nosocomial pathogen that leads to respiratory tract infections and urinary tract. Due to the increasing of antibiotic resistance in S. maltophilia, treatment of infections caused by these bacteria has been difficult. The aims of this study was detection of antibiotic resistance pattern and identify of class I and II integrons and associated gene cassettes in clinical isolates of S. maltophilia.

Materials and Methods: In this cross-sectional study, of 246 clinical specimen were collected from educational hospitals of Hamadan university of medical sciences, 12 isolates of
S. maltophilia were collected in 2015. After the culture, isolates were verified by standard biochemical methods. Antibiotic susceptibility was determined against 13 antibiotics. Presence of Class I and II integrons genes were tested using specific primers by PCR.

Results: In the pattern of antibiotic resistance, the highest resistance rate showed to Cefditoren, Ceftriaxone, Cefotaxime antibiotics and the lowest resistance to Amikacin, Imipenem, Ofloxacin, Trimethoprim-Sulphamethoxazole and Ciprofloxacin antibiotics were reported. All S. maltophilia strains carried class I integrons. No isolate carry class II integrons and gene cassettes.

Conclusions: The result of this study indicates a high prevalence of class I integrons in
S.maltophilia isolates. Thus, identification of these resistance genes for infection control programs and to prevent the spread of resistant strains is very important.

Keywords: Stenotrophomonas maltophilia isolates, Integron, Antibiotic resistance

Full-Text [PDF 424 kb] (2765 Downloads)

Type of Study: Original Research Article | Subject: Medical Bacteriology
Received: 2016/03/10 | Accepted: 2016/07/25 | ePublished: 2016/10/17

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