Insights into the Role of pslA and pslB Genes in Biofilm-Mediated Multidrug Resistance of Pseudomonas aeruginosa

Shadbash, Piruz; Bahari Babadi, Marzieh

year 20, Issue 1 (January - February 2026) Iran J Med Microbiol 2026, 20(1): 63-65 | Back to browse issues page

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Shadbash P, Bahari Babadi M. Insights into the Role of pslA and pslB Genes in Biofilm-Mediated Multidrug Resistance of Pseudomonas aeruginosa. Iran J Med Microbiol 2026; 20 (1) :63-65
URL: http://ijmm.ir/article-1-2939-en.html

Insights into the Role of pslA and pslB Genes in Biofilm-Mediated Multidrug Resistance of Pseudomonas aeruginosa

Piruz Shadbash¹

, Marzieh Bahari Babadi²

1- Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran & Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran , shadbashpiruz@gmail.com
2- Department of Biochemistry, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract: (296 Views)

Dear Editor,
We read with great interest the article by Amini et al. (Iran J Med Microbiol. 2025;19(3):150–8), titled “Prevalence of pslA and pslB Biofilm-Related Genes in Pseudomonas aeruginosa Isolates from ICU Patients: A Cross-Sectional PCR-Based Study.” The authors’ investigation into biofilm-associated genes among multidrug-resistant (MDR) Pseudomonas aeruginosa isolates from intensive care unit (ICU) patients provides valuable insight into the molecular basis of biofilm formation and antibiotic resistance in clinical settings.
The reported prevalence of pslA (98.9%) and pslB (100%) genes in biofilm-forming isolates is striking, emphasizing the genetic uniformity and clinical persistence of P. aeruginosa strains within ICU environments. These findings are particularly significant given the global rise in carbapenem-resistant P. aeruginosa and the increasing burden of device-associated infections. The strong correlation between pslA/pslB gene presence and MDR phenotypes reinforces the concept that biofilm formation is not merely a survival strategy but an integrated resistance mechanism that shields bacterial communities from antimicrobial agents and host immune responses.

Keywords: pslA, pslB, Pseudomonas aeruginosa, ICU Patients

Full-Text [PDF 369 kb] (19 Downloads)

Type of Study: Letter to the Editor | Subject: Medical Bacteriology
Received: 2025/12/3 | Accepted: 2026/02/7 | ePublished: 2026/02/28

References

1. Amini ME, Razavi S, Rahbar M, Eslami P. Prevalence of pslA and pslB Biofilm-Related Genes in Pseudomonas aeruginosa Isolates from ICU Patients: A Cross-Sectional PCR-Based Study. Iran J Med Microbiol. 2025;19(3):150-8. [DOI:10.30699/ijmm.19.3.150]

2. Wang M, Shi Q, Sun W, Lin J, Chen X, Shen Y, et al. Epidemiology of device-associated healthcare-associated infections and carbapenem-resistant Enterobacteriaceae in intensive care units: a 7-year multicenter surveillance in Shanghai, China. Infect. Control Hosp Epidemiol. 2025;46(10):992-8. [DOI:10.1017/ice.2025.10292] [PMID]

3. Mikkelsen H, Sivaneson M, Filloux A. Key two‐component regulatory systems that control biofilm formation in Pseudomonas aeruginosa. Environ Microbiol. 2011;13(7):1666-81. [DOI:10.1111/j.1462-2920.2011.02495.x] [PMID]