year 2, Issue 3 And 4 (3-2009)
Iran J Med Microbiol 2009, 2(3 And 4): 59-65 |
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Shirazi M H, Akbari A, Sharifi Yazdi M K, Hosseini M, Fardsanei F, Bakhtiari R et al . Antibiotic resistance patterns of enteropathogenic E.coli(EPEC) serogroups isolated from stool of under 5 years old children with diarrhea in Tehran:2007- 2008. Iran J Med Microbiol 2009; 2 (3 and 4) :59-65
URL: http://ijmm.ir/article-1-130-en.html
URL: http://ijmm.ir/article-1-130-en.html
Mohammad Hasan Shirazi1 
, Abolfazl Akbari1 , Mohammad kazem Sharifi Yazdi2 , Mostafa Hosseini3 , Fatemeh Fardsanei1 , Ronak Bakhtiari1 , Mohammad Mehdi Soltan Dallal 4
, Abolfazl Akbari1 , Mohammad kazem Sharifi Yazdi2 , Mostafa Hosseini3 , Fatemeh Fardsanei1 , Ronak Bakhtiari1 , Mohammad Mehdi Soltan Dallal 4
1- Division of Microbiology, Department of Pathobiology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences (TUMS). Tehran, Iran
2- Department of Laboratory Medicine, Faculty Paramedical Sciences, Tehran University of Medical Sciences. Tehran, Iran
3- Department of Epidemiology and Biostatics, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences.Tehran, Iran
4- Division of Microbiology, Department of Pathobiology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences (TUMS). Tehran, Iran ,soltanirad34@yahoo.com
2- Department of Laboratory Medicine, Faculty Paramedical Sciences, Tehran University of Medical Sciences. Tehran, Iran
3- Department of Epidemiology and Biostatics, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences.Tehran, Iran
4- Division of Microbiology, Department of Pathobiology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences (TUMS). Tehran, Iran ,
Abstract: (16830 Views)
Background and objectives: Enteropathogenic E.coli (EPEC) strains have high prevalence in children and
are of the most important diarrheagenic agents in developed and developing countries that may cause severe
diarrhea even death. Prevalence and antibiotic resistance patterns differ in different geographic areas.
Knowledge of the patterns is necessary for physicians in order to treatment of infections using appropriate
antibiotics. This research aimed to detection of common EPEC serogroups in diarrheal under 5 year old
children and study the patterns of antibiotic resistance of these strains.
Materials and Methods: 278 samples collected from children with diarrhea visited in Ali Asghar hospital, Tehran. Bacterial isolates confirmed as EPEC serogroups on the basis of standard biochemical and serological tests. Antibiotic susceptibility testing was performed using 16 different antibiotic discs by disc diffusion agar (Kirby-Bauer) method.
Results: In this study 19 strains (6.8%) of EPEC isolated that prevalence of EPEC strains particularly serogroup poly IV was more common in children under one year old. All strains were sensitive to meropenem and imipenem, 63.2 % were resistant to nalidixic acid, tetracycline and amoxicillin and 89.5 % of strains were sensitive to ceftazidime and gentamycin. Results indicated that most strains completely or intermediately were resistant to nalidixic acid, tetracycline and amoxicillin.
Conclusion: Antibiotic resistance of EPEC strains to nalidixic acid ,tetracyclin and amoxiciline is increasing. Due to increasing resistance towards antibiotics, we should use new and effective antibiotics according to antibiotic susceptibility testing for treatment of infections
Materials and Methods: 278 samples collected from children with diarrhea visited in Ali Asghar hospital, Tehran. Bacterial isolates confirmed as EPEC serogroups on the basis of standard biochemical and serological tests. Antibiotic susceptibility testing was performed using 16 different antibiotic discs by disc diffusion agar (Kirby-Bauer) method.
Results: In this study 19 strains (6.8%) of EPEC isolated that prevalence of EPEC strains particularly serogroup poly IV was more common in children under one year old. All strains were sensitive to meropenem and imipenem, 63.2 % were resistant to nalidixic acid, tetracycline and amoxicillin and 89.5 % of strains were sensitive to ceftazidime and gentamycin. Results indicated that most strains completely or intermediately were resistant to nalidixic acid, tetracycline and amoxicillin.
Conclusion: Antibiotic resistance of EPEC strains to nalidixic acid ,tetracyclin and amoxiciline is increasing. Due to increasing resistance towards antibiotics, we should use new and effective antibiotics according to antibiotic susceptibility testing for treatment of infections
Type of Study: Original Research Article |
Subject:
Antibiotic Resistance
Received: 2013/11/16 | Accepted: 2013/11/16 | ePublished: 2013/11/16
Received: 2013/11/16 | Accepted: 2013/11/16 | ePublished: 2013/11/16
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