سال 16، شماره 6 - ( آذر - دی 1401 )                   جلد 16 شماره 6 صفحات 505-490 | برگشت به فهرست نسخه ها


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Rostamian M, Kadivarian S, Kooti S, Dashtbin S, Abiri R, Alvandi A. Prevalence of Extended-Spectrum Beta-Lactamase in Gram Negative Bacteria Isolated from Kermanshah Medical Centers: A Systematic Review and Meta-Analysis. Iran J Med Microbiol 2022; 16 (6) :490-505
URL: http://ijmm.ir/article-1-1691-fa.html
رستمیان مصیب، کدیوریان سپیده، کوتی سارا، دشتبین شیرین، عبیری رامین، الوندی امیرهوشنگ. شیوع بتالاکتاماز های طیف گسترده در باکتری های گرم منفی جدا شده از مراکز درمانی کرمانشاه: یک مرور سیستماتیک و متاآنالیز. مجله میکروب شناسی پزشکی ایران. 1401; 16 (6) :490-505

URL: http://ijmm.ir/article-1-1691-fa.html


1- مرکز تحقیقات بیماری‌های عفونی، پژوهشکده سلامت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
2- گروه میکروبشناسی، دانشکده پزشکی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
3- گروه میکروبشناسی، دانشکده پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران
4- مرکز تحقیقات باروری و ناباروری، پژوهشکده فناوری سلامت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
5- مرکز تحقیقات تکنولوژی پزشکی، پژوهشکده فناوری سلامت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران ، ah_alvandi@kums.ac.ir
چکیده:   (2582 مشاهده)
زمینه و اهداف:  عفونت‌های بیمارستانی ناشی از باکتری‌های گرم منفی از مهم‌ترین چالش‌های تهدیدکننده سلامت قرن حاضر به‌ویژه پس از ظهور و گسترش سویه‌های مقاوم به آنتی‌بیوتیک هستند. بتالاکتاماز های طیف گسترده (ESBL)، یکی از مهم ترین مکانیسم های مقاومت آنتی بیوتیکی، در حال گسترش در سراسر جهان است. نظارت و جمع‌آوری داده‌ها در مورد شیوع مقاومت آنتی‌بیوتیکی و ژن‌های کدکننده مرتبط با آن‌ها می‌تواند به انتخاب استراتژی‌ها و سیاست‌های درمانی کمک کند. این مرور سیستماتیک و متاآنالیز به منظور بررسی شیوع باکتری‌های ESBL مثبت و ژن‌های مقاومت آن‌ها در مراکز درمانی شهر کرمانشاه، غرب ایران طراحی شد.
مواد و روش کار:  تمام مطالعات منتشر شده به عنوان مقالات اصیل با جستجو در پایگاه‌های اطلاعاتیEMBASE ، Scopus، PubMed/Medline، Google Scholar  و پایگاه های فارسی SID و Magiran با استفاده از کلمات کلیدی مناسب بدون محدودیت زمانی تا ۳۰ مارس ۲۰۲۲ وارد شدند. برای تجزیه و تحلیل داده ها از نرم افزار جامع متاآنالیز استفاده شد.
یافته ها:  شیوع باکتری های ESBL مثبت و مقاومت دارویی چندگانه (MDR) در مراکز درمانی کرمانشاه به ترتیب ۳۴/۸% و ۵۶/۱% بود. بیشترین و کمترین شیوع باکتری ESBL مثبت به ترتیب برای انتروباکتر کلوآکه (۵۹/۱۴%) و سودوموناس آئروژینوزا (۴/۵۵%) مشاهده شد. بیشترین و کمترین شیوع ژن های مقاومت به ترتیب برای blaOXA-۵۱  (۹۹/۳%) و  blaKPC (۰/۶%)  مشاهده شد. بیشترین مقاومت به آنتی بیوتیک مزولوسیلین (۹۲/۲%) برآورد شد.
نتیجه‌گیری:  این مطالعه نشان داد که شیوع باکتری‌های ESBL مثبت و MDR در مراکز درمانی کرمانشاه بالا است و اطلاعات قابل‌توجهی را در اختیار سیاست‌گذاران سلامت قرار می‌دهد تا راه کارهای مناسب برای کاهش شیوع باکتری‌های مقاوم را اجرا کنند.
متن کامل [PDF 2382 kb]   (755 دریافت)    
نوع مطالعه: مقاله متا آنالیز | موضوع مقاله: باکتری شناسی پزشکی
دریافت: 1400/12/15 | پذیرش: 1401/4/7 | انتشار الکترونیک: 1401/6/18

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