Role of Plant-Derived Prebiotic in Modulation of Human Gut Microflora: A Review

Rajput, Khushboo; Dohroo, Aradhana; Devgon, Inderpal; Karnwal, Arun

doi:10.30699/ijmm.16.5.368

year 16, Issue 5 (September - October 2022) Iran J Med Microbiol 2022, 16(5): 368-375 | Back to browse issues page

‎ 10.30699/ijmm.16.5.368

Mendeley

Zotero

RefWorks

Rajput K, Dohroo A, Devgon I, Karnwal A. Role of Plant-Derived Prebiotic in Modulation of Human Gut Microflora: A Review. Iran J Med Microbiol 2022; 16 (5) :368-375
URL: http://ijmm.ir/article-1-1670-en.html

Role of Plant-Derived Prebiotic in Modulation of Human Gut Microflora: A Review

Khushboo Rajput¹

, Aradhana Dohroo²

, Inderpal Devgon¹

, Arun Karnwal

1- Department of Microbiology, School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Delhi G.T. Road, National Highway 1, Phagwara, Punjab 144411, India
2- Baddi University of Emerging Sciences and Technologies, Baddi, Himachal Pradesh- 173405, India
3- Department of Microbiology, School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Delhi G.T. Road, National Highway 1, Phagwara, Punjab 144411, India , arunkarnwal@gmail.com

Abstract: (1714 Views)

At the time of the coevolution of humans and microorganisms, the human digestive tract was colonized by thousands of species of bacteria. Mostly, intestine-borne microbes amount to the overall number of cells in the body tissue. The latest metagenomics study of the human intestinal microbiota confirmed the existence of some 3.3 million genes relative to only 23,000 genes found in tissue cells in the human body. There is increasing evidence for multiple beneficial functions of the gut microbiota in human health and illness. The best-described plant prebiotics is fructans and inulin. The best-known prebiotic carbohydrates comprise many plants, roots and tubers, and fruit crops, whereas prebiotic-richer grain crops contain maize, chickpea, lentil, lupin, and wheat. Some prebiotic enriched crop germplasm were documented in maize, chickpea, lentil, wheat, and yacon. Intestinal microbiota perturbation may contribute to persistent diseases such as autoimmune diseases, bowel cancers, stomach ulcers, colon disorders, and malnutrition. This can be impossible to recover the intestinal microbiome, but the usage of probiotics has contributed to a positive effect in a significant number of very well-designed (clinical) trials. Microbiomics has prompted a significant growth of interest in probiotics and prebiotics as potential mediators for the administration and regulation of gut microbiota in medicine, industry, and the general public. Developing prebiotic-rich healthy plants can mitigate the prevalent malnutrition challenge and facilitate worldwide global health. Bioinformatics and genomics tools may help to create mechanistic associations between gut microflora, a person's health status, and the outcomes of plant prebiotic drug treatments.

Keywords: Microbiota, Intestinal microbes, Microbiomics, Plant-derived carbohydrates, Probiotics

Full-Text [PDF 482 kb] (712 Downloads) | | Full-Text (HTML) (674 Views)

Type of Study: Review Article | Subject: Food Microbiology
Received: 2022/02/15 | Accepted: 2022/05/18 | ePublished: 2022/08/8

References

1. Xu X, Jia X, Mo L, Liu C, Zheng L, Yuan Q, et al. Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis. Bone Res. 2017;5(1):1-18. [DOI:10.1038/boneres.2017.46] [PMID] [PMCID]

2. Conlon MA, Bird AR. The impact of diet and lifestyle on gut microbiota and human health. Nutrients. 2014;7(1):17-44. [DOI:10.3390/nu7010017] [PMID] [PMCID]

3. Sridharan GV, Choi K, Klemashevich C, Wu C, Prabakaran D, Pan LB, et al. Prediction and quantification of bioactive microbiota metabolites in the mouse gut. Nat. Commun. 2014;5(1):1-13. [DOI:10.1038/ncomms6492] [PMID]

4. Mills RH, Vázquez-Baeza Y, Zhu Q, Jiang L, Gaffney J, Humphrey G, et al. Evaluating metagenomic prediction of the metaproteome in a 4.5-year study of a patient with Crohn's disease. Msystems. 2019;4(1):e00337-18. [DOI:10.1128/mSystems.00337-18] [PMID] [PMCID]

5. Martín R, Miquel S, Ulmer J, Kechaou N, Langella P, Bermúdez-Humarán LG. Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease. Microb Cell Factories. 2013;12(1):1-11. [DOI:10.1186/1475-2859-12-71] [PMID] [PMCID]

6. Bindels LB, Delzenne NM, Cani PD, Walter J. Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol. 2015;12(5):303-10. [DOI:10.1038/nrgastro.2015.47] [PMID]

7. Gibson GR, al e. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502. [DOI:10.1038/nrgastro.2017.75] [PMID]

8. Floch MH, Walker WA, Madsen K, Sanders ME, Macfarlane GT, Flint HJ, et al. Recommendations for probiotic use-2011 update. J Clin Gastroenterol. 2011;45:S168-S71. [DOI:10.1097/MCG.0b013e318230928b] [PMID]

9. Kechagia M, Basoulis D, Konstantopoulou S, Dimitriadi D, Gyftopoulou K, Skarmoutsou N, et al. Health benefits of probiotics: a review. Int Sch Res Notices. 2013;2013. [DOI:10.5402/2013/481651] [PMID] [PMCID]

10. Vrese Md, Schrezenmeir. Probiotics, prebiotics, and synbiotics. Food Biotechnol. 2008:1-66. [DOI:10.1007/10_2008_097] [PMID]

11. Pandey K, Naik S, Vakil B. Probiotics, prebiotics and synbiotics-a review. J Food Sci Technol. 2015;52(12):7577-87. [DOI:10.1007/s13197-015-1921-1] [PMID] [PMCID]

12. Dwivedi S, Sahrawat K, Puppala N, Ortiz R. Plant prebiotics and human health: Biotechnology to breed prebiotic-rich nutritious food crops. Electron J Biotechnol. 2014;17(5):238-45. [DOI:10.1016/j.ejbt.2014.07.004]

13. Holscher HD. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes. 2017;8(2):172-84. [DOI:10.1080/19490976.2017.1290756] [PMID] [PMCID]

14. Yoo H-D, Kim D, Paek S-H. Plant cell wall polysaccharides as potential resources for the development of novel prebiotics. Biomol Ther. 2012;20(4):371. [DOI:10.4062/biomolther.2012.20.4.371] [PMID] [PMCID]

15. Patel S, Goyal A. The current trends and future perspectives of prebiotics research: a review. 3 Biotech. 2012;2(2):115-25. [DOI:10.1007/s13205-012-0044-x] [PMCID]

16. Lin B, Gong J, Wang Q, Cui S, Yu H, Huang B. In-vitro assessment of the effects of dietary fibers on microbial fermentation and communities from large intestinal digesta of pigs. Food Hydrocolloids. 2011;25(2):180-8. [DOI:10.1016/j.foodhyd.2010.02.006]

17. Campos D, Betalleluz-Pallardel I, Chirinos R, Aguilar-Galvez A, Noratto G, Pedreschi R. Prebiotic effects of yacon (Smallanthus sonchifolius Poepp. & Endl), a source of fructooligosaccharides and phenolic compounds with antioxidant activity. Food Chem. 2012;135(3):1592-9. [DOI:10.1016/j.foodchem.2012.05.088] [PMID]

18. Huang C-H, Cheng J-Y, Deng M-C, Chou C-H, Jan T-R. Prebiotic effect of diosgenin, an immunoactive steroidal sapogenin of the Chinese yam. Food Che. 2012;132(1):428-32. [DOI:10.1016/j.foodchem.2011.11.016] [PMID]

19. Lu QY, Summanen PH, Lee RP, Huang J, Henning SM, Heber D, et al. Prebiotic potential and chemical composition of seven culinary spice extracts. J Food Sci. 2017;82(8):1807-13. [DOI:10.1111/1750-3841.13792] [PMID] [PMCID]

20. Romo-Vaquero M, Selma M-V, Larrosa M, Obiol M, García-Villalba R, González-Barrio R, et al. A rosemary extract rich in carnosic acid selectively modulates caecum microbiota and inhibits β-glucosidase activity, altering fiber and short chain fatty acids fecal excretion in lean and obese female rats. PloS One. 2014;9(4):e94687. [DOI:10.1371/journal.pone.0094687] [PMID] [PMCID]

21. Al-Thubiani AS, Khan MSA. The prebiotic properties of date palm (phoenix dactylifera L.) seeds in stimulating probiotic Lactobacillus. J Pure Appl Microbiol. 2017;11(4):1675-86. [DOI:10.22207/JPAM.11.4.05]

22. Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients. 2017;9(9):1021. [DOI:10.3390/nu9091021] [PMID] [PMCID]

23. Grajek W, Olejnik A, Sip A. Probiotics, prebiotics and antioxidants as functional foods. Acta Biochim Pol. 2005;52(3):665-71. [DOI:10.18388/abp.2005_3428] [PMID]

24. Kumar M, Kumar A, Nagpal R, Mohania D, Behare P, Verma V, et al. Cancer-preventing attributes of probiotics: an update. Int J Food Sci Nutr. 2010;61(5):473-96. [DOI:10.3109/09637480903455971] [PMID]

25. Mariat D, Firmesse O, Levenez F, Guimarăes VD, Sokol H, Doré J, et al. The Firmicutes/ Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol. 2009;9(1):1-6. [DOI:10.1186/1471-2180-9-123] [PMID] [PMCID]

26. Kleessen B, Blaut M. Modulation of gut mucosal biofilms. Br J Nutr. 2005;93(S1):S35-S40. [DOI:10.1079/BJN20041346] [PMID]

27. Wong JMW, De Souza R, Kendall CWC, Emam A, Jenkins DJA. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006;40(3):235-43. [DOI:10.1097/00004836-200603000-00015] [PMID]

28. Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, et al. regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009;461(7268):1282-6. [DOI:10.1038/nature08530] [PMID] [PMCID]

29. Hemarajata P, Versalovic J. Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therap Adv Gastroenterol. 2013;6(1):39-51. [DOI:10.1177/1756283X12459294] [PMID] [PMCID]

30. Scholz-Ahrens KE, Adolphi B, Rochat F, Barclay DV, de Vrese M, Açil Y, et al. Effects of probiotics, prebiotics, and synbiotics on mineral metabolism in ovariectomized rats-impact of bacterial mass, intestinal absorptive area and reduction of bone turn-over. Nfs Journal. 2016;3:41-50. [DOI:10.1016/j.nfs.2016.03.001]

31. Vulevic J, Drakoularakou A, Yaqoob P, Tzortzis G, Gibson GR. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr. 2008;88(5):1438-46.

32. Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux J-J, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci. 2008;105(43):16731-6. [DOI:10.1073/pnas.0804812105] [PMID] [PMCID]