Background and objective: Methicillin resistant Staphylococcus aureus(MRSA) is a main cause of nosocomial infections worldwide. Multidrug resistance property of strains causes difficulties in treatment of their infection. The aim of this study was to determine the frequency of MRSA and their resistance pattern to commonly used antibiotics in Health-educational centers of Gorgan. Material and Methods: In this descriptive study, 121 clinical isolates of Staphylorcoccus aureuscollected from different infections from September 2008 to August 2009. After confirmatory identification tests, the antibiotic susceptibility testing was performed by using disk diffusion method as per Clinical and Laboratory Standards Institute(CLSI) guideline. Data analyzed by Chi-square test and SPSS soft ware. P value of <0.05 was determined as significant. Results: Of 121 tested S.aureus, 104(85.9%)strains were MRSA. The highest resistance was demonstrated as:100% to Penicillin, 97.6% to CO- Amoxyclav ,71.4% to Cephotaxime and64.3% to Erythromycin. Our finding showed more MRSA isolates in urine (90.4%) and wound (89.2%) specimens. Conclusion: Prevalence of MRSA strains in our region was 85.9% .This is higher than other studies performed in major cities such as Tehtan,Mashhad and Shiraz . The treatment of infections caused by MRSA is difficult due to simultaneous multidrug resistance among the strains

Keywords: MRSA, Antimicrobial resistant, Disk diffusion

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