year 3, Issue 2 And 3 (12-2009)                   Iran J Med Microbiol 2009, 3(2 And 3): 21-26 | Back to browse issues page

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1- Department of Microbiology & Immunology, Kashan University of Medical Sciences
2- Department of Microbiology & Immunology, Kashan University of Medical Sciences , moniri@kaums.ac.ir
3- Department of Statistics, School of Health, Kashan University of Medical Sciences
Abstract:   (17652 Views)
Background and Objectives: During the last decade, enterococci have become important nosocomial pathogens, representing the second leading cause of urinary tract infections. This increasing prevalence has been paralleled by the occurrence of multi-drug resistant (MDR). The aim of this cross-sectional prevalence study was to determine the prevalence and risk factors of antibiotic resistance of Enterococcus faecium isolated from clinical samples in hospitalized patients in Kashan, Iran.
Material and Methods: This descriptive study was done on clinical specimens isolated from hospitalized patients, from September 2007 to 2008. A total of 106 E. faecalis strains were isolated from collected specimens. Antimicrobial susceptibility test was determined with disk diffusion method as per CLSI instructions. The minimal inhibitory concentration of vancomycin assayed by E test.
Results: From 128 isolated enterococci, 106(82.8 %) were identified as Enterococcus faecalis and 22 (17.2%) were Enterococcus faecium. According to the results of susceptibility testing, the resistance rates for E.faecalis were as follows: erytromycin 56(52.8%), ciprofloxacin 43(40.6%), gentamicin 41(38.7%), levofloxacin36(34%),penicillin 31(29.2%),nitrofurantoin 20(18.8%), ampicillin 12(11.3%), Imipenem 11(10.4%), and vancomycin 6(4.7%). All isolates were sensitive to linezolid. Multidrug-resistant (MDR) phenotype (resistance to three or more of drugs) occurred in 40(37.7%) of the isolates.
Conclusion: Emergence of multidrug-resistant E.faecalis and high level resistance to vancomycin shown by E.faecalis strains is of concern because of the limitation in the therapeutic options for treatment of infections caused by enterococci.
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Type of Study: Original Research Article | Subject: Antibiotic Resistance
Received: 2013/11/22 | Accepted: 2013/11/22 | ePublished: 2013/11/22

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