year 15, Issue 3 (May - Jun 2021)
Iran J Med Microbiol 2021, 15(3): 361-368 |
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Gevik Karpians1 
, Vahhab Piranfar 2, Isar Yahyavi3 , Teni Sepanian1 , Tadeh Sepanian1 , Samaneh Alizadeh4 , Arefeh Chandhal5
, Vahhab Piranfar 2, Isar Yahyavi3 , Teni Sepanian1 , Tadeh Sepanian1 , Samaneh Alizadeh4 , Arefeh Chandhal5
1- Department of Biochemistry, Medical Laboratory, Tehran, Iran
2- Research and Development Department, Farname Inc, Thornhill, Canada , vahab.p@gmail.com
3- Department of Molecular, Medical laboratory, Tehran, Iran
4- Department of Hematology, Medical Laboratory, Tehran, Iran
5- Department of Phlebotomy, Medical laboratory, Tehran, Iran
2- Research and Development Department, Farname Inc, Thornhill, Canada , vahab.p@gmail.com
3- Department of Molecular, Medical laboratory, Tehran, Iran
4- Department of Hematology, Medical Laboratory, Tehran, Iran
5- Department of Phlebotomy, Medical laboratory, Tehran, Iran
Abstract: (11597 Views)
Background and Objective: Coronavirus disease known as COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is affecting over 200 countries all over the world. This study was aimed to identify simple and swiftly available laboratory biomarkers to help facilitate effectual triage to categorize suspected COVID-19 patients.
Materials and Methods: According to a standard protocol, we collected clinical, etiological, and laboratory data of 140 patients who underwent diagnostic tests at Medical Laboratory Group, Tehran, Iran, from October 1 to November 28, 2020, based on PCR testing for SARS-CoV-2 infection. Leukocyte parameters, C-reactive protein (CRP) and, ferritin levels were measured in patients with positive PCR COVID-19 test.
Results: 140 patients with COVID-19 infection were included in the study. The median age in women was 41.5 (23-60) years and 45.3 (22-68) years in men. Based on RT-PCR result, there were significant differences for neutrophil, lymphocyte, and monocyte counts. Overall, 72.8% of patients had monocyte count more than 11 ×109 /L. The mean neutrophil lymphocyte ratio (NLR) for women was 2.8 (SD: 1.8) and 2.6 (SD: 1.7) for men. Only in 15 patients (10.7%) with respiratory symptoms, CRP level was more than 5 mg/L.
Conclusion: We found a significant increase in monocyte count. Lymphopenia was also observed. In patients with respiratory symptoms, CRP was significantly higher than the normal reference range.
Keywords: Acute respiratory distress syndrome, Coronavirus, Cytokine release syndrome, Lymphopenia, Real Time PCR, Severe acute respiratory syndrome
Type of Study: Original Research Article |
Subject:
Medical Virology
Received: 2021/03/18 | Accepted: 2021/05/22 | ePublished: 2021/06/28
Received: 2021/03/18 | Accepted: 2021/05/22 | ePublished: 2021/06/28
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