en باکتری شناسی پزشکی Medical Bacteriology نامه به سردبیر Letter to the Editor <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span new="" roman="" times=""><strong><span style="font-weight:normal">Dear Editor,</span></strong></span><br> <span new="" roman="" times="">We read with great interest the article by Amini et al. (Iran J Med Microbiol. 2025;19(3):150&ndash;8), titled <em data-end="573" data-start="431">&ldquo;Prevalence of pslA and pslB Biofilm-Related Genes in Pseudomonas aeruginosa Isolates from ICU Patients: A Cross-Sectional PCR-Based Study.&rdquo;</em> The authors&rsquo; investigation into biofilm-associated genes among multidrug-resistant (<em data-end="663" data-start="658">MDR</em>) <em data-end="689" data-start="665">Pseudomonas aeruginosa</em> isolates from intensive care unit (ICU) patients provides valuable insight into the molecular basis of biofilm formation and antibiotic resistance in clinical settings.</span><br> <span new="" roman="" times="">The reported prevalence of <em data-end="893" data-start="887">pslA</em> (98.9%) and <em data-end="912" data-start="906">pslB</em> (100%) genes in biofilm-forming isolates is striking, emphasizing the genetic uniformity and clinical persistence of <em data-end="1045" data-start="1030">P. aeruginosa</em> strains within ICU environments. These findings are particularly significant given the global rise in carbapenem-resistant <em data-end="1184" data-start="1169">P. aeruginosa</em> and the increasing burden of device-associated infections. The strong correlation between <em data-end="1286" data-start="1275">pslA/pslB</em> gene presence and MDR phenotypes reinforces the concept that biofilm formation is not merely a survival strategy but an integrated resistance mechanism that shields bacterial communities from antimicrobial agents and host immune responses.</span></span></span></p> pslA, pslB, Pseudomonas aeruginosa, ICU Patients 63 65 http://ijmm.ir/browse.php?a_code=A-10-2674-3&slc_lang=en&sid=1 Piruz Shadbash shadbashpiruz@gmail.com 100319475328460034297 0009-0008-1328-482X Yes Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Marzieh Bahari Babadi marziye.bahari2019@gmail.com 100319475328460034298 0009-0002-9280-389X No Department of Biochemistry, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran