year 2, Issue 1 (Spring 2008)                   Iran J Med Microbiol 2008, 2(1): 53-58 | Back to browse issues page

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The effect of Sub-Minimum Inhibitory Concentration (S-MIC) of ciprofloxacin & ampicillin on hemolysin activity of Escherichia coli
Seyed Asghar Havaei 1, Morteza Satari2 , Mojgan Oshaghi2 , Abdolrazagh Hashemi Shahraki3
1- Department of Microbiology , Isfahan University of Medical Sciences , havaei @med.mui.ac.ir
2- Department of Microbiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran.
3- Department of Microbiology , Isfahan University of Medical Sciences
Abstract:   (15716 Views)
Background and objectives: Sub-minimum inhibitory concentration (S-MIC) can induce changes in morphology, virulence factors and biochemical properties ofbacterial pathogens. The goal of this study is to determine the Sub-MIC effect of ciprofloxacin and ampicillin on the haemotytic activity of E. coli.
Material and Methods:Two clinical isolates of E. coli with high heamolytic activity was selected. Changes in haemolytic activity of the isolates was assessed after exposing them to MIC and Sub-MIC of ciprofloxacin and ampicillin.
Results: Ciprofloxacin decreased haemolytic activity at 1/2, 1/4 and 1/8 Sub-Mic, whereas ampicillin showed no effect on haemolytic activity.
Conclusion: We conclude that Sub-MIC concentrations of ciprofloxacin decreased the haemolytic activity of E. coli, wherease ampicillin had no such effect
Keywords: Mycobacterium bovis, Mycobacterium tuberculosiscomplex, oxyRpseudogene, PCR-RFLP, AluI
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Type of Study: Original Research Article | Subject: Medical Bacteriology
Received: 2013/11/14 | Accepted: 2013/11/14 | ePublished: 2013/11/14
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